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Fig. 3 | Human Genomics

Fig. 3

From: Loss-of-function mutations in MYO15A and OTOF cause non-syndromic hearing loss in two Yemeni families

Fig. 3

MYO15A gene structure, electropherograms, and in silico analysis. A The location of the identified variant with respect to the MYO15A gene. Solid rectangles represent coding regions. B Electropherograms of a homozygous mutant profile (top panel), a heterozygous profile (middle panel), and a homozygous wild-type profile (bottom panel) for the c.6347delA variant in the MYO15A gene. C pathogenicity predicted impact of the c.6347delA variant at protein level. IQ: Calmodulin-binding motif. MyTH4: Myosin Tail Homology 4. FERM: (4.1, ezrin, radixin, and meosin). SH3 SRC Homology 3. PDZ Post-synaptic density protein

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Human Genomics

ISSN: 1479-7364