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Fig. 6 | Human Genomics

Fig. 6

From: A heterozygous mutation in UBE2H in a patient with developmental delay leads to an aberrant brain development in zebrafish

Fig. 6

Depletion of ube2h disrupts the maintenance of neurons during zebrafish embryogenesis. A, B Dorsal view of confocal microscopy images of AO staining (Green) of the brains of ube2h morphants and uninjected controls with the transgenic background of either ngn:RFP (A) or huc:DsRed (B). at 24 hpf. Yellow arrowheads indicate either ngn- or huc-positive cells (red). C, D Lateral view of confocal microscopy images of AO staining in the body trunk of ube2h morphants and uninjected controls with the ngn:RFP (C) and huc:DsRed (D) transgenic background. The white dotted box indicates the ngn-positive dorsal area, while yellow bracket indicates the huc-positive ventral area in the neural tube

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Human Genomics

ISSN: 1479-7364