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  2. The Cytochrome P450 Homepage is a universal resource for nomenclature and sequence information on cytochrome P450 (CYP) genes. The site has been in continuous operation since February 1995. Currently, naming info...

    Authors: David R. Nelson
    Citation: Human Genomics 2009 4:59
    Content type: Genome databases Published on:

  3. The rate of change in genomics, and 'omics generally, shows no signs of slowing down. Related analysis software is struggling to keep apace. This paper provides a brief review of the field.

    Authors: Michael E Weale
    Citation: Human Genomics 2009 4:56
    Content type: Software review Published on:

  5. Candidate gene studies are generally motivated by some form of pathway reasoning in the selection of genes to be studied, but seldom has the logic of the approach been carried through to the analysis. Marginal...

    Authors: Duncan C. Thomas, David V. Conti, James Baurley, Frederik Nijhout, Michael Reed and Cornelia M. Ulrich
    Citation: Human Genomics 2009 4:21
    Content type: Review Published on:

  6. With the trend in molecular epidemiology towards both genome-wide association studies and complex modelling, the need for large sample sizes to detect small effects and to allow for the estimation of many para...

    Authors: Courtney Gray-McGuire, Murielle Bochud, Robert Goodloe and Robert C. Elston
    Citation: Human Genomics 2009 4:2
    Content type: Primary research Published on:

  8. Genotype imputation for single nucleotide polymorphisms (SNPs) has been shown to be a powerful means to include genetic markers in exploratory genetic association studies without having to genotype them, and i...

    Authors: David Ellinghaus, Stefan Schreiber, Andre Franke and Michael Nothnagel
    Citation: Human Genomics 2009 3:371
    Content type: Software review Published on:

  9. Aldo-keto reductases (AKRs) are phase I metabolising enzymes that catalyse the reduced nicotinamide adenine dinucleotide (phosphate) (NAD(P)H)-dependent reduction of carbonyl groups to yield primary and secondary...

    Authors: Rebekka D. Mindnich and Trevor M. Penning
    Citation: Human Genomics 2009 3:362
    Content type: Genome review Published on:

  10. One of the hallmarks of bacterial survival is their ability to adapt rapidly to changing environmental conditions. Niche adaptation is a response to the signals received that are relayed, often to regulators t...

    Authors: Deepak Balasubramanian and Kalai Mathee
    Citation: Human Genomics 2009 3:349
    Content type: Review Published on:

  12. The diversity of hosts, pathogens and host-pathogen relationships reflects the influence of selective pressures that fuel diversity through ongoing interactions with other rapidly evolving molecules in the env...

    Authors: Meena K. Sakharkar, Kishore R. Sakharkar and Vincent T.K. Chow
    Citation: Human Genomics 2009 3:320
    Content type: Review Published on:

  14. This paper reports the identification of a novel cytosolic aldehyde dehydrogenase 1 (ALDHIAI) allele. One hundred and sixty-two Indo-Trinidadian and 85 Afro-Trinidadian individuals were genotyped. A novel ALDHIAI

    Authors: Shelley M. Moore, Tiebing Liang, Tamara J. Graves, Kevin M. McCall, Lucinda G. Carr and Cindy L. Ehlers
    Citation: Human Genomics 2009 3:304
    Content type: Primary research Published on:

  18. There exist four fundamentally different classes of membrane-bound transport proteins: ion channels; transporters; aquaporins; and ATP-powered pumps. ATP-binding cassette (ABC) transporters are an example of A...

    Authors: Vasilis Vasiliou, Konstandinos Vasiliou and Daniel W. Nebert
    Citation: Human Genomics 2009 3:281
    Content type: Genome review Published on:

  20. The past few decades have witnessed much progress in the field of pharmacogenetics. The identification of the genetic background that regulates the antidepressant response has benefited from these advances. Th...

    Authors: Antonio Drago, Diana De Ronchi and Alessandro Serretti
    Citation: Human Genomics 2009 3:257
    Content type: Review Published on:

  21. Microbial communities play vital roles in many aspects of our lives, although our understanding of microbial biogeography and community profiles remains unclear. The number of microbes or the diversity of the ...

    Authors: Melissa Doud, Erliang Zeng, Lisa Schneper, Giri Narasimhan and Kalai Mathee
    Citation: Human Genomics 2009 3:246
    Content type: Research Published on:

  23. Transcription factors are key mediators of human complex disease processes. Identifying the target genes of transcription factors will increase our understanding of the biological network leading to disease ri...

    Authors: Tianyuan Wang, Terrence S Furey, Jessica J Connelly, Shihao Ji, Sarah Nelson, Steffen Heber, Simon G Gregory and Elizabeth R Hauser
    Citation: Human Genomics 2009 3:221
    Content type: Research Published on:

  29. Pharmacogenetics enables personalised therapy based on genetic profiling and is increasingly applied in drug discovery. Medicines are developed and used together with pharmacodiagnostic tools to achieve desire...

    Authors: Alice Matimba, Jurgen Del-Favero, Christine Van Broeckhoven and Collen Masimirembwa
    Citation: Human Genomics 2009 3:169
    Content type: Primary research Published on:

  30. A large body of evidence suggests that the environment plays an important role in the development of obesity. The hormone-sensitive lipase (encoded by the LIPE gene) is an intracellular enzyme that mobilises fat ...

    Authors: Christophe Garenc, Marie-Claude Vohl, Claude Bouchard and Louis Pérusse
    Citation: Human Genomics 2009 3:157
    Content type: Primary research Published on:

  32. Carboplatin is a chemotherapeutic agent used in the management of many cancers, yet treatment is limited by resistance and toxicities. To achieve a better understanding of the genetic contribution to carboplat...

    Authors: Sunita J. Shukla, Shiwei Duan, Xiaolin Wu, Judith A. Badner, Kristen Kasza and M. Eileen Dolan
    Citation: Human Genomics 2009 3:128
    Content type: Primary research Published on:

  33. Alcoholism is a complex behavioural disorder. Molecular genetics studies have identified numerous candidate genes associated with alcoholism. It is crucial to verify the disease susceptibility genes by correla...

    Authors: Giia-Sheun Peng and Shih-Jiun Yin
    Citation: Human Genomics 2009 3:121
    Content type: Review Published on:

  34. Succinic semialdehyde dehydrogenase (SSADH; aldehyde dehydrogenase 5A1 [ALDH5A1]; locus 6p22) occupies a central position in central nervous system (CNS) neurotransmitter metabolism as one of two enzymes neces...

    Authors: Patrizia Malaspina, Matthew J. Picklo, C. Jakobs, O. Carter Snead and K. Michael Gibson
    Citation: Human Genomics 2009 3:106
    Content type: Review Published on:

  38. The olfactory receptor gene (OR) superfamily is the largest in the human genome. The superfamily contains 390 putatively functional genes and 465 pseudogenes arranged into 18 gene families and 300 subfamilies. Ev...

    Authors: Tsviya Olender, Doron Lancet and Daniel W. Nebert
    Citation: Human Genomics 2008 3:87
    Content type: Genome update Published on:

  40. Mitochondria, the powerhouse of the cell, play a critical role in several metabolic processes and apoptotic pathways. Many lines of evidence suggest that mitochondria have a central role in ageing-related neur...

    Authors: Michelangelo Mancuso, Massimiliano Filosto, Daniele Orsucci and Gabriele Siciliano
    Citation: Human Genomics 2008 3:71
    Content type: Review Published on:

  42. In genetic association studies, deviation from Hardy-Weinberg equilibrium (HWD) can be due to recent admixture or selection at a locus, but is most commonly due to genotyping errors. In addition to its utility...

    Authors: Srijan Sen and Margit Burmeister
    Citation: Human Genomics 2008 3:36
    Content type: Primary research Published on:

  43. Liver cystolic aldehyde dehydrogenase 1 (ALDH1A1) has been previously associated with both alcohol dependence and alcohol consumption behaviour, and has been implicated in alcohol-induced flushing and alcohol ...

    Authors: Penelope A. Lind, C. J. Peter Eriksson and Kirk C. Wilhelmsen
    Citation: Human Genomics 2008 3:24
    Content type: Primary research Published on:

  44. There is considerable inter-ethnic variability in the incidence of CYP2C19 genetic poor metabolisers (var/var). About 3 per cent of Caucasians are CYP2C19 var/var. By contrast, an extremely high incidence (70 per...

    Authors: Huai-Ling Hsu, Kathryn J. Woad, D. Graeme Woodfield and Nuala A. Helsby
    Citation: Human Genomics 2008 3:17
    Content type: Primary research Published on:

  45. Polymorphisms in drug transporter genes and/or drug-metabolising enzyme genes may contribute to inter-individual variability in rosiglitazone pharmacokinetics in humans. We sought to determine the joint effect...

    Authors: Christina L Aquilante, Lane R. Bushman, Shannon D. Knutsen, Lauren E. Burt, Lucille Capo Rome and Lisa A. Kosmiski
    Citation: Human Genomics 2008 3:7
    Content type: Primary research Published on:

  48. A variety of techniques exist to describe and depict patterns of pairwise linkage disequilibrium (LD). In the current paper, a new log-linear framework is proposed for the summarisation of local interactions a...

    Authors: A. P. Mander and A. Bansal
    Citation: Human Genomics 2006 2:376
    Content type: Primary research Published on:
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