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Table 1 qPCR and WGSA results on c-MYC and p16 genes

From: Whole genome DNA copy number changes identified by high density oligonucleotide arrays

c-Mycregion on chromosome 8
Marker/sample SNP 55150 (300 kb distal) SNP 511315 (196 kb distal)
   12ΔCt+1 2WGSA 3Sig   2ΔCt+1 WGSA Sig
Sk-BR-3   32.00 15.87 < - 20   22.63 21.12 - 11.89
MCF-7   9.19 4.54 - 3.47   7.46 6.25 - 1.89
ZR-75-30   13.00 7.64 -7.67   11.31 16.31 -9.95
Hs578 Bst   2.60 2.54 -0.86   2.64 3.21 -0.77
p 16 region on chromosome 9
Marker/sample SNP 827951 (235 kb proximal) SNP 139369 (inside p 16) SNP 87445 (21 kb distal)
  2 ΔCt+1 WGSA Sig 2 ΔCt+1 WGSA Sig 2 ΔCt+1 WGSA Sig
BT-20 1.82 1.92 -0.31 0.008 0.23 -12.06 1.32 1.57 -0.71
MCF-12A 1.29 1.02 -1.46 0.014 0.27 -10.44 0.08 0.57 -8.12
MCF-7 1.33 1.82 -0.37 0.002 0.25 -10.83 1.00 0.95 -2.68
Hs578 Bst 2.28 1.87 -0.35 1.073 1.61 -0.60 1.23 1.75 -0.56
  1. 12Δct+1: Copy number estimated by quantitative polymerase chain reaction.
  2. 2WGSA: Copy number estimated by whole genome sampling analysis assay.
  3. 3Sig: Log10 (p-value). p -value is derived from the presented algorithm by comparing the target sample to a reference set consisting of normal people. SNP, single nucleotide polymorphism.