Skip to content

Advertisement

Featured article: Integrating rare genetic variants into pharmacogenetic drug response predictions

Variability in genes implicated in drug pharmacokinetics or drug response can modulate treatment efficacy or predispose to adverse drug reactions. Besides common genetic polymorphisms, recent sequencing projects revealed a plethora of rare genetic variants in genes encoding proteins involved in drug metabolism, transport, and response. The data reveal high gene and drug specificity in the contributions of rare variants. A proof-of-concept is provided on how this information can be utilized to pinpoint genes for which sequencing-based genotyping can add important information to predict drug response, which provides useful information for the design of clinical trials in drug development and the personalization of pharmacological treatment.

Articles

Most accessed articles RSS

View all articles

HGNC updates

Updates from the HUGO Gene Nomenclature Committee (HGNC) relevant to Human Genomics readers.

Previous content

Human Genomics launched with BioMed Central in July 2012, transferring from its previous publisher Henry Stewart Publications. All back content is now available in the archive.

Aims and scope

Human Genomics is a peer-reviewed, open access journal that focuses on the application of genomic analysis in all aspects of human health and disease, as well as genomic analysis of drug efficacy and safety, and comparative genomics.

Call for Papers: Public Health Genomics

Guest Editors: George P Patrinos, University of Patras, Greece; Hongyu Zhao, Yale University, USA

Papers are invited which address current issues in human public health genomics, such as genomic surveillance of disease, genetic risk prediction, individual genome interpretation, gene-environment interactions, genetic diversity of vector-borne disease, vaccination and vaccine-based approaches against pathogens data sharing, economic evaluation in genomic medicine, and the role of big data and artificial intelligence on the development of translational tools and services and the overall future of public health.

Submission Deadline: March 2019

Latest Tweets

Meeting Announcement

Kidgen logo

Symposium: Renal Genomics -Translating the Potential

8-9 September, 2018 at the International Convention Centre, Darling Harbour, Sydney in conjunction with the ANZSN Annual Scientific Meeting 2018.

Invited international speakers:
Anna Greka,  Broad Institute of MIT and Harvard 
Phil Beales, Great Ormond Street ICH

Advertisement

2017 Journal Metrics

Advertisement