Updates from the HUGO Gene Nomenclature Committee (HGNC) relevant to Human Genomics readers.
Featured article: COVID-19 vulnerability: the potential impact of genetic susceptibility and airborne transmission
With the high number of COVID-19 cases, it is apparent that SARS-CoV-2 is easily transmitted and there are large variations in disease severity. This review highlights the importance of exploring the contribution of aerosol transmission of SARS-CoV-2 as means for understanding an approach for prevention infections. Further related to preventions, the role of genetic susceptibility and resistance to SARS-CoV-2 exposure and its associated disease is discussed. This will be key to better understand makes some SARS-CoV-2 infected individuals extremely sensitive while others are asymptomatic.
Articles
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Novel biallelic loss-of-function variants in CEP290 cause Joubert syndrome in two siblings
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Application of CRISPR/Cas9 to human-induced pluripotent stem cells: from gene editing to drug discovery
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Whole-genome sequencing of Chinese centenarians reveals important genetic variants in aging WGS of centenarian for genetic analysis of aging
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Genomics of COVID-19: molecular mechanisms going from susceptibility to severity of the disease
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Ernst Wit and John McClure John Wiley & Sons Ltd, Chichester, UK, 2004
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The X chromosome and sex-specific effects in infectious disease susceptibility
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Intragraft transcriptional profiling of renal transplant patients with tubular dysfunction reveals mechanisms underlying graft injury and recovery
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Self-reported race/ethnicity in the age of genomic research: its potential impact on understanding health disparities
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Survival analysis tools in genomics research
HGNC updates
Previous content
Human Genomics launched with BioMed Central in July 2012, transferring from its previous publisher Henry Stewart Publications. All back content is now available in the archive.
From the Blog
COVID-19 and impact on peer review
As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times. Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.
Aims and scope
Human Genomics is a peer-reviewed, open access journal that focuses on the application of genomic analysis in all aspects of human health and disease, as well as genomic analysis of drug efficacy and safety, and comparative genomics.
Call for papers: Genomics of COVID-19: Molecular Mechanisms Going from Susceptibility to Severity of the Disease
The current COVID-19 pandemic has highlighted the importance of science and medicine, specifically public health, in our modern societies. Countries have taken different approaches to the pandemic. Science and medicine will play an important role in our way forward in tackling COVID-19. Specifically, genetics and genomics will be central in discovering variations in virus strains and their impact on patients’ outcome, the hosts’ ability to fend off the virus and the severity of disease in patients. Furthermore, the question of long-term immunity to COVID-19 may have a genetic and genomic basis which should be investigated. Some of these human genetics and genomics investigations will undoubtedly be suitable for publication in Human Genomics. We expressly welcome submissions of manuscripts on such subjects.
Guest Editors: Giuseppe Novelli, Italy; Juergen Reichardt, Australia
Call for Papers: Genetically Manipulated Animal Models for Human Disease
Guest Editors: Ying Chen, Yale University, USA; Won Yeong Kang, The Jackson Laboratory, USA; Hassane Mchaourab, Vanderbilt University, USA
In recent decades, genetically manipulated animal models have been developed and used widely in the biomedical research field. Use of animal models thus serves as an important tool to elucidate mechanisms of human disease, as well as to develop new diagnostic and therapeutic strategies for the treatment of these diseases. In this topical collection, we intend to provide up-to-date information on recent genetic animal models, and new knowledge derived from these studies on the pathophysiology, diagnosis and therapeutic drugs of human disease. We invite investigators to contribute original research and review articles that describe: (i) newly developed animal models, (ii) intervention studies using animal models, and (iii) comparisons between existing models for certain diseases.
Submission Deadline: December 2021
Call for Papers: Public Health Genomics
Guest Editors: George P Patrinos, University of Patras, Greece; Hongyu Zhao, Yale University, USA
Papers are invited which address current issues in human public health genomics, such as genomic surveillance of disease, genetic risk prediction, individual genome interpretation, gene-environment interactions, genetic diversity of vector-borne disease, vaccination and vaccine-based approaches against pathogens data sharing, economic evaluation in genomic medicine, and the role of big data and artificial intelligence on the development of translational tools and services and the overall future of public health.
Submission Deadline: December 2020
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Annual Journal Metrics
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Speed
54 days first decision for reviewed manuscripts only
41 days to first decision for all manuscripts
110 days from submission to acceptance
27 days from acceptance to publicationCitation Impact
3.351 - 2-year Impact Factor
3.745 - 5-year Impact Factor
0.885 - Source Normalized Impact per Paper (SNIP)
1.594 - SCImago Journal Rank (SJR)Usage
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