Human Genomics

Featured article:A novel knowledge-derived data potentizing method revealed unique liver cancer-associated genetic variants

Over the past decade, next-generation sequencing (NGS) has led to advances in the detection of disease-associated genetic variants and genome-wide profiling of expressed sequences by enabling the analyses of multiple regions of a genome in a single format. NGS has also led to the development of personalized and precision medicine in clinical practice.  In this study, Sultana et al. explore a panel of previously unaddressed liver cancer-associated variants using a novel data prioritizing rationale.  This method of data curing could lead to more effective screening of global genetic variants related to disease onset, progression, and remission since the raw NGS data reports numerous non-specific mutations simply due to naturally occurring genetic variation.