Figure 2

The pharmacokinetics of debrisoquine in CYP2D6-humanised mice. Time course of serum concentrations of (A) debriso-quine (DEB) and (B) 4-hydroxydebrisoquine (4-OH-DEB) from wild-type, CYP2D6-humanised heterozygous and CYP2D6-humanised homozygous mice after one single oral administration of DEB (2.5 mg/kg). Venous blood was obtained 0, 0.5, 1, 2, 4, 6, 8, 12 and 24 hours after DEB administration. Values represent the mean and the vertical lines the standard errors of the mean of DEB and 4-OH-DEB from three mice