Emerging strategies and applications of pharmacogenomics

Table 1 Selected examples of pharmacogenomics studies investigating currently available therapies.

Therapeutic	Indication	Phenotype investigated	Gene/genomic relationship	References
Carbamazepine	Seizures	Stevens-Johnson syndrome	HLA-B* 1502	[56]
Metoprolol	Hypertension	Blood pressure lowering	Beta-1 adrenergic receptor	[57]
Abacavir	HIV	Hypersensitivity	HLA-B* 5701	[58, 59]
			HLA-DR7
			HLA-DQ3
Raloxifene	Osteoporosis	Bone mineral density	Vitamin D receptor	[60]
Tolcapone	Parkinson's disease	Elevated liver transaminase levels	UDP-glucuronosyltransferase 1A	[61]
Azathiopurine, mercaptopurine, thioguanine	Childhood leukaemia	Drug exposure	Thiopurine S-methyltransferase-inactivating mutation	[62]
Zileuton	Asthma	FEV1 response	5-lipoxygenase promoter variant	[63]
Fluvoxamine	Depression	Drug response based on Hamilton Depression Rating Scale	Serotonin transporter	[64]
Sertraline	Depression	Time to therapeutic response	Serotonin transporter	[65]
Enalaprilat	Hypertension	Blood pressure lowering	ACE Ins/Del	[66]

ACE = angiotensin-converting enzyme; FEV1 = forced expiratory volume in one second.

ISSN: 1479-7364