Table 1 Genes responsible for inherited deafness (DFN) with neighbouring microsatellite markers used in the subgenome scan.
Chromosome | Distance from pter (MB) | Gene | DFN locus | Size of gene (kb) | Flanking markers and kb spanned | ||
|---|---|---|---|---|---|---|---|
1 p36.31 | 6.4 | ESPN | B36 | 36 | D1S253 | D1S2731 | 342 |
1 p34.3 | 34.9 | GJB3 | A2 | 5 | D 1S1570 | D1S496 | 190 |
1 p34.2 | 40.9 | KCNQ4 | A2 | 55 | D1S2706 | D1S1188 | 273 |
2 p23.3 | 26.6 | OTOF | B9 | 102 | D2S2350 | D2S174 | 112 |
3 p21.31 | 46.7 | TMIE | B6 | 9 | AC(46.635) | TG(46.779) | 144 |
4 p16.1 | 6.4 | WFS1 | A6/A14 | 33 | TCCC(6.457) | D4S431 | 77 |
5 q31.3 | 140.9 | DIAPH1 | A1 | 104 | D5S2119 | D5S2010 | 254 |
5 q32 | 145.7 | POU4F3 | A15 | 1 | D 5S2099 | D5S2033 | 628 |
6 p21.32 | 33.2 | COL11A2 | A13 | 30 | D6S2414 | D6S1701 | 449 |
6 q14.1 | 76.6 | MY O6 | B37/A22 | 167 | AC (76.528) | GT(76.674) | 146 |
6 q23.2 | 133.7 | EYA4 | A10 | 288 | D6S975 | D6S1722 | 517 |
7 p15.3 | 24.5 | DFN A5 | A5 | 51 | D7S2444 | D7S2493 | 477 |
7 q22.1 | 102.6 | SLC26A5 (Prestin) | B61 | 93 | D7S2509 | D7S2504 | 478 |
7 q31.1 | 106.9 | SLC26A4 (Pendrin) | B4 | 57 | D7S496 | D7S2459 | 177 |
8 q22.3 | 102.6 | TFCP2L3 | A28 | 177 | D8S521 | D8S1046 | 761 |
9 q21.13 | 72.4 | TMC1 | B7/B11/A36 | 315 | D9S1837 | D9S1876 | 48 |
9 q32 | 114.3 | WHRN | B31 | 103 | D9S1824 | D9S1855 | 619 |
10 p12.1 | 26.4 | MY03A | B30 | 278 | D10S2481 | D10S1775 | 60 |
10 q21.1 | 56.0 | PCDH15 | B23 | 980 | D10S546 | D10S1642 | 321 |
10 q22.1 | 73.0 | CDH23 | B12 | 420 | D10S584 | D10S1694 | 152 |
11 p15.1 | 17.5 | USH1C (Harmonin) | B18 | 51 | D11S902 | D11S4138 | 268 |
11 q13.5 | 76.6 | MY07A | B2/A11 | 87 | D11S4179 | D11S4186 | 573 |
11 q23.3 | 120.5 | TECTA | B21/A8/A12 | 88 | D11S4089 | D11S4107 | 60 |
12 q13.3 | 55.7 | MY O1A | A48 | 22 | D12S1644 | D12S1691 | 1 |
13 q12.11 | 19.7 | GJB2 (Connexin26) | B1/A3 | 5 | D 13S1316 | D13S175 | 167 |
13 q12.11 | 19.7 | GJB6 (Connexin31) | B1/A3 | 9 | D 13S1316 | D13S175 | 167 |
14 q12 | 30.4 | COCH | A9 | 16 | D14S1021 | D14S54 | 256 |
15 q15.3 | 41.7 | STRC | B16 | 19 | TG(41.690) | TG(41.707) | 17 |
16 p12.2 | 21.2 | CRYM | A40 | 20 | D16S3045 | TTA(21.603) | 661 |
16 p12.2 | 21.6 | OTOA | B22 | 82 | D16S3045 | TTA(21.603) | 661 |
17 p11.2 | 18.0 | MY015A | B3 | 71 | AC (17.958) | AA T(18.013) | 55 |
17 q25.3 | 77.1 | ACTG1 | A20/A26 | 3 | G T(77.007) | CA (77.107) | 100 |
19 q13.33 | 55.4 | MYH14 | A4 | 107 | D19S866 | D19S904 | 22 |
21 q22.13 | 36.8 | CLDN14 | B29 | 20 | D21S1252 | D21S167 | 369 |
21 q22.3 | 42.7 | TMPRSS3 | B8/B10 | 25 | D21S1225 | GT(43.277) | 740 |
22 q12.3 | 35.1 | MYH9 | A1720 | 107 | D22S1173 | D22S283 | 115 |
22 q13.1 | 36.4 | TRIOBP | B28 | 89 | TG(36.464) | CA (36.494) | 30 |