Figure 3

Correlation between DNA methylation and gene expression. DNA methylation data derived from the Human Epigenome Pilot Project were grouped according to 5'-UTR being methylated or unmethylated and the body of the gene being methylated or unmethylated. Each group was then plotted against the corresponding Genomics Institute of the Novartis Research Foundation (GNF) http://symatlas.gnf.org/SymAtlas expression level, which is set to anything below 200 as not being expressed and anything above 200 as being expressed. This cluster analysis shows that genes with methylated 5'-UTRs are silent and genes with unmethylated 5'-UTRs are expressed. In this study, no correlation was found between expression and the methylation level within the body of the gene. Reproduced from Rakyan et al. [51]