Genetic factors leading to chronic Epstein-Barr virus infection and nasopharyngeal carcinoma in South East China: Study design, methods and feasibility

Table 5 Group 2: Markers and alleles showing significant allele frequencies among IgA⁺ cases without NPC and IgA^- subjects.

cM	Locus	Individuals#			Allele freq(%)			Dominant			Recessive
		Allele	IgA+	IgA -	IgA+		IgA 2	OR	p value	95% CI	OR	pvalue	95% CI
37.64	D4S2950	137	230	319	13.3	<	18.5	0.56	0.004	0.38-0.83	0.75	0.56	0.28-2.00
40.14	D4S190	170	236	332	23.9	>	18.7	1.40	0.06	0.98-1.99	2.38	0.04	1.03-5.49
40.75	D4S174	202	237	331	23.4	<	32.6	0.59	0.003	0.42-0.84	0.33	0.002	0.16-0.67
43.27	D4S3357	271	232	326	34.3	>	27.8	1.51	0.02	1.06-2.13	1.46	0.20	0.82-2.61
44.09	D4S1627	218	239	335	33.3	<	38.1	0.81	0.24	0.58-1.15	0.57	0.039	0.33-0.97
44.48	D4S3241	136	233	325	13.7	>	8.9	1.91	0.004	1.24-2.94	2.11	0.28	0.54-8.27
45.71	D4S2381	301	238	330	18.9	<	23.0	0.70	0.05	0.49-1.0	0.90	0.80	0.42
45.84	D4S1536	284	233	327	33.7	<	40.7	0.79	0.19	0.56-1.13	0.48	0.01	0.27-0.84
52.95	D4S1577	143	238	332	34.2	<	41.6	0.70	0.05	0.49-1.0	0.52	0.01	0.31-0.86
53.03	D4S3347	213	237	332	34.8	>	29.5	1.65	0.004	1.17-2.33	0.89	0.67	0.50-1.56
53.03	D4S3347	217	237	332	45.4	<	50.0	0.87	0.48	0.59-1.28	0.66	0.05	0.43-1.0
54.86	D4S1594	266	236	330	66.1	>	64.2	1.76	0.04	1.02-3.03	1.01	0.95	0.71-1.43

Abbreviations: CI, confidence interval; cM, centimorgan; IgA, immunoglobulin A; OR, odds ratio.

ISSN: 1479-7364