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Table 3 Genotypic and allelic analysis of the ALDH1A1 rs348479, rs6l0529 and rs348449 polymorphisms in Finnish controls, problem drinkers and clinically treated alcoholic subjects

From: The role of aldehyde dehydrogenase-1 (ALDH1A1) polymorphisms in harmful alcohol consumption in a Finnish population

SNPa and groupb Number Group mean AUDIT score MAF (%) Genotype Genotypic Allelic
        p-valuec OR (95% Cl)d pvaluec OR (95% Cl)d
rs348479     GG GT TT   (TT and TG) vs GG   
   controls 105 6.26 18.1 6.7 22.9 70.4 Ref Ref Ref Ref
   problem 64 28.27 18.0 3.1 29.7 67.2 0.4 1.01 (0.57-1.79) 1.0 1.01 (0.57-1.79)
   alcoholic 104 27.74 14.9 0 29.8 70.2 0.019 N/A 0.4 1.26 (0.75-2.12)
rs610529     AA AG GG   GG vs (GA and AA)   
   controls 105 6.26 39.5 37.1 46.7 16.2 Ref Ref Ref Ref
   problem 64 28.27 37.5 35.9 53.1 10.9 0.6 0.92 (0.58-1.44) 0.7 0.92 (0.58-1.44)
   alcoholic 104 27.74 29.8 46.1 48.1 5.8 0.045 0.32 (0.12-0.84) 0.040 0.65 (0.43-0.98)
rs348449     AA AG GG   AA vs (AG and GG)   
   controls 105 6.26 1.0 98.1 1.9 0 Ref Ref Ref Ref
   problem 64 28.27 7.0 87.5 10.9 1.6 0.017 7.36 (1.51-35.84) 0.003 7.87 (1.67-37.01)
   alcoholic 104 27.74 3.4 93.3 6.7 0 0.09 3.72 (0.75-18.33) 0.1 3.62 (0.74-17.64)
  1. aThe population (n = 305) SNP allele frequencies are as follows: rs348479 G allele frequency = 0.17, rs610529 G allele frequency = 0.37 and rs348449 G allele frequency = 0.03.
  2. bThe three groups are: (1) Controls (AUDIT score ≤ 12); (2) Problem drinkers (AUDIT score ≥20, not treated for alcoholism); and (3) Clinically treated alcoholics.
  3. cGenotype and allele distributions of the problem drinkers and treated alcoholic subjects were each compared with those in the control group using two-sided Pearson's chi-square or Fisher exact tests, respectively.
  4. dOdds ratios (OR) and Wald 95% confidence intervals (95% CI) were determined separately for the allele and genotype counts of problem drinkers and treated alcoholic subjects versus control drinkers. Genotype odds ratios for each SNP were calculated as follows: rs348479 (GG versus [GT and TT]), rs6l0529 ([AA and AG] versus GG) and rs348449 (AA versus [AG and GG]).
  5. Abbreviations: MAF, minor allele frequency; N/A, not applicable; Ref, reference group.