The role of aldehyde dehydrogenase-1 (ALDH1A1) polymorphisms in harmful alcohol consumption in a Finnish population

Table 3 Genotypic and allelic analysis of the ALDH1A1 rs348479, rs6l0529 and rs348449 polymorphisms in Finnish controls, problem drinkers and clinically treated alcoholic subjects

SNP^a and group^b	Number	Group mean AUDIT score	MAF (%)	Genotype			Genotypic			Allelic
							p-value^c	OR (95% Cl)^d	pvalue^c	OR (95% Cl)^d
rs348479				GG	GT	TT		(TT and TG) vs GG
controls	105	6.26	18.1	6.7	22.9	70.4	Ref	Ref	Ref	Ref
problem	64	28.27	18.0	3.1	29.7	67.2	0.4	1.01 (0.57-1.79)	1.0	1.01 (0.57-1.79)
alcoholic	104	27.74	14.9	0	29.8	70.2	0.019	N/A	0.4	1.26 (0.75-2.12)
rs610529				AA	AG	GG		GG vs (GA and AA)
controls	105	6.26	39.5	37.1	46.7	16.2	Ref	Ref	Ref	Ref
problem	64	28.27	37.5	35.9	53.1	10.9	0.6	0.92 (0.58-1.44)	0.7	0.92 (0.58-1.44)
alcoholic	104	27.74	29.8	46.1	48.1	5.8	0.045	0.32 (0.12-0.84)	0.040	0.65 (0.43-0.98)
rs348449				AA	AG	GG		AA vs (AG and GG)
controls	105	6.26	1.0	98.1	1.9	0	Ref	Ref	Ref	Ref
problem	64	28.27	7.0	87.5	10.9	1.6	0.017	7.36 (1.51-35.84)	0.003	7.87 (1.67-37.01)
alcoholic	104	27.74	3.4	93.3	6.7	0	0.09	3.72 (0.75-18.33)	0.1	3.62 (0.74-17.64)

^aThe population (n = 305) SNP allele frequencies are as follows: rs348479 G allele frequency = 0.17, rs610529 G allele frequency = 0.37 and rs348449 G allele frequency = 0.03.
^bThe three groups are: (1) Controls (AUDIT score ≤ 12); (2) Problem drinkers (AUDIT score ≥20, not treated for alcoholism); and (3) Clinically treated alcoholics.
^cGenotype and allele distributions of the problem drinkers and treated alcoholic subjects were each compared with those in the control group using two-sided Pearson's chi-square or Fisher exact tests, respectively.
^dOdds ratios (OR) and Wald 95% confidence intervals (95% CI) were determined separately for the allele and genotype counts of problem drinkers and treated alcoholic subjects versus control drinkers. Genotype odds ratios for each SNP were calculated as follows: rs348479 (GG versus [GT and TT]), rs6l0529 ([AA and AG] versus GG) and rs348449 (AA versus [AG and GG]).
Abbreviations: MAF, minor allele frequency; N/A, not applicable; Ref, reference group.

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