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Supplementary Table 2 Genes whose expression levels were associated with the cytotoxicity of perifosine (FDRBH < 0.10) but were not perifosine specific

From: Genome-wide identification of genetic determinants for the cytotoxicity of perifosine

Symbol

Gene title

r

p

Control totala

GL-U95

    

FNBP3

Formin-binding protein 3

-0.53

3.5E-05

75

MOBKL2A

MOBI, Mps One Binder kinase activator-like 2A (yeast)

-0.50

5.5E-05

43

TP53INP2

Tumour protein p53 inducible nuclear protein 2

0.51

3.9E-05

24

FBXO44

F-box protein 44

0.52

2.4E-05

53

TMF1

TATA element modulatory factor 1

0.53

1.7E-05

57

NP-U95

    

HNRPDL

Heterogeneous nuclear ribonucleoprotein D-like

-0.49

6.9E-05

3

DDX39

DEAD (Asp-Glu-Ala-Asp) box polypeptide 39

-0.49

7.3E-05

22

MRPL23

Mitochondrial ribosomal protein L23

-0.49

8.7E-05

2

RPS24

Ribosomal protein S24

-0.47

1.9E-04

21

LBR

Lamin B receptor

-0.47

2.0E-04

73

ERCC5

Excision repair cross-complementing rodent repair deficiency, complementation group 5

-0.47

2.0E-04

11

HDAC1

Histone deacetylase 1

-0.46

2.2E-04

2

GTF3A

General transcription factor IIIA

-0.45

3.IE-04

11

EEF1B2

Eukaryotic translation elongation factor 1 beta 2

-0.44

4.3E-04

68

ICAM3

Intercellular adhesion molecule 3

-0.44

5.IE-04

43

SNRPF

Small nuclear ribonucleoprotein polypeptide F

-0.44

5.2E-04

83

SH2D1A

SH2 domain protein IA, Duncan's disease (lymphoproliferative syndrome)

-0.44

5.8E-04

61

KIR3DL1

Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1

-0.43

7.3E-04

76

RPL35

Ribosomal protein L35

-0.42

8.IE-04

47

NUPL2

Nucleoporin-like 2

-0.42

8.8E-04

1

PTMA

Prothymosin, alpha (gene sequence 28)

-0.42

9.0E-04

33

CORO1A

Coronin, actin-binding protein, IA

-0.42

9.3E-04

104

LCNI

Lipocalin 1 (tear prealbumin)

-0.42

9.3E-04

21

POLE3

Polymerase (DNA directed), epsilon 3 (pl7 subunit)

-0.42

9.2E-04

31

RPS27A

Ribosomal protein S27a

-0.42

9.4E-04

79

TRIMI4

Tripartite motif-containing 14

-0.42

9.3E-04

60

LHFPL2

Lipoma HMGIC fusion partner-like 2

0.42

l.0E-03

99

DOK5

Docking protein 5

0.42

9.5E-04

l

EIF4GI

Eukaryotic translation initiation factor 4 gamma, l

0.42

9.6E-04

28

RGSI9

Regulator of G-protein signalling 19 interacting protein l

0.42

9.2E-04

116

COPB2

Coatomer protein complex, subunit beta 2 (beta prime)

0.42

8.9E-04

l

TLE2

Transducin-like enhancer of split 2 (E(spl) homologue, Drosophila)

0.42

9.0E-04

4

ITGA7

Integrin, alpha 7

0.42

8.6E-04

13

SEMA3C

Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C

0.42

8.2E-04

22

SI00AI3

S100 calcium binding protein A13

0.43

7.8E-04

88

FLOTI

Flotillin 1

0.43

6.5E-04

2

MLFI

Myeloid leukemia factor 1

0.43

6.0E-04

11

ARHGEFII

Rho guanine nucleotide exchange factor (GEF) 11

0.44

5.5E-04

9

COLI5AI

Co11agen, type XV, alpha l

0.44

4.9E-04

l

DAGI

Dystroglycan l (dystrophin-associated glycoprotein l)

0.44

4.9E-04

118

IFNAI4

Interferon alpha l4

0.44

4.8E-04

2

PHLDBI

Pleckstrin homology-like domain, family B, member l

0.44

4.5E-04

12

PTPRS

Protein tyrosine phosphatase, receptor type S

0.45

4.0E-04

2

SASHI

SAM and SH3 domain containing l

0.45

4.lE-04

52

ACVRIB

Activin A receptor, type IB

0.45

3.2E-04

18

CTNNAI

Catenin (cadherin-associated protein), alpha 1, 102 kDa

0.46

3.0E-04

30

IL6ST

Interleukin 6 signal transducer (gp130, oncostatin M receptor)

0.46

2.9E-04

68

ATP6VID

ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D

0.46

2.5E-04

2

SUOX

Sulphite oxidase

0.46

2.1E-04

58

TFAP2A

Transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)

0.48

1.3E-04

51

GRINA

Glutamate receptor, ionotropic, N-methyl D-asparate-associated protein 1 (glutamate binding)

0.49

9.3E-05

1

ABCB6

ATP-binding cassette, sub-family B (MDR/ TAP), member 6

0.49

8.2E-05

8

CTSF

Cathepsin F

0.49

7.4E-05

9

VEGFB

Vascular endothelial growth factor B

0.50

4.6E-05

6

GGCX

Gamma-glutamyl carboxylase

0.52

2.1E-05

23

LAPTM4B

Lysosomal-associated protein transmembrane 4 beta

0.53

1.6E-05

84

FYN

Sialidase 1 (lysosomal sialidase)

0.55

6.3E-06

59

NS-cDNA

    

LBR

Lamin B receptor

-0.47

1.3E-04

1

TRA2A

Transformer-2 alpha

-0.44

8.3E-04

13

ETS2

V-ets erythroblastosis virus E26 oncogene homolog 2 (avian)

-0.44

5.3E-04

30

UBE2D3

Ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homologue, yeast)

-0.42

8.5E-04

4

RRMI

Ribonucleotide reductase M1 polypeptide

-0.41

9.8E-04

1

ATP6VICI

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C, isoform 1

0.42

7.7E-04

51

VEGFB

Vascular endothelial growth factor B

0.44

6.3E-04

57

RDX

Radixin

0.45

4.2E-04

29

APOD

Apolipoprotein D

0.45

3.1E-04

3

PTMS

Parathymosin

0.47

1.8E-04

2

  1. aThe total number of associated standard agents (see Methods).
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Human Genomics

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