Table 2 Human ABC transporter genes, and their functions, as listed in the HGNC database

ABCA1

9q3l.l

36

2261

NM005502

Cholesterol efflux onto HDL

ABCA2

9q34

27

2436

NM001606

Drug resistance

ABCA3

16pl3.3

26

1704

NM001089

Multidrug resistance

ABCA4

1p22

38

2273

NM000350

N-retinylidene-phosphatidylethanolamine (PE) efflux

ABCA5

17q24.3

31

1642

NM018672

Urinary diagnostic marker for prostatic intraepithelial neoplasia (PIN)

ABCA6

17q24.3

35

1617

NM080284

Multidrug resistance

ABCA7

19p13.3

31

2146

NM019112

Cholesterol efflux

ABCA8

17q24

31

1581

NM007168

Transports certain lipophilic drugs

ABCA9

17q24.2

31

1624

NM080283

Might play a role in monocyte differentiation and macrophage lipid homeostasis

ABCA10

l7q24

27

1543

NM080282

Cholesterol-responsive gene

ABCA12

2q34

37

2595

NM173076

Has implications for prenatal diagnosis

ABCA13

7p12.3

36

5058

NM152701

Inherited disorder affecting the pancreas

ABCB1

7q21.1

20

1280

NM000927

Multidrug resistance

ABCB2 (TAPI)

6p21.3

11

808

NM000593

Peptide transport

ABCB3 (TAP2)

6p21.3

11

703

NM000544

Peptide transport

ABCB4

7q21.1

25

1279

NM000443

Phosphatidylcholine (PC) transport

ABCB5

7p15.3

17

812

NM178559

Melanogenesis

ABCB6

2q36

19

842

NM005689

Iron transport

ABCB7

Xq12-q13

14

753

NM004299

Fe/S cluster transport

ABCB8

7q36

15

718

NM007188

Intracellular peptide trafficking across membranes

ABCB9

12q24

12

766

NM019625

Located in lysosomes

ABCB10

1q42.13

13

738

NM012089

Export of peptides derived from proteolysis of inner-membrane proteins

ABCB11

2q24

26

1321

NM003742

Bile salt transport

ABCC1

16p13.1

31

1531

NM004996

Drug resistance

ABCC2

10q24

26

1545

NM000392

Organic anion efflux

ABCC3

17q22

19

1527

NM003786

Drug resistance

ABCC4

13q32

19

1325

NM005845

Nucleoside transport

ABCC5

3q27

25

1437

NM005688

Nucleoside transport

ABCC6

16p13.1

28

1503

NM001171

Expressed primarily in liver and kidney

ABCC7 (CFTR)

7q31.2

23

1480

NM000492

Chloride ion channel (same as CFTR gene in cystic fibrosis)

ABCC8

11p15.1

30

1581

NM000352

Sulfonylurea receptor

ABCC9

12p12.1

32

1549

NM005691

Encodes the regulatory SUR2A subunit of the cardiac K⁺(ATP) channel

ABCC10

6p21.1

19

1464

NM033450

Multidrug resistance

ABCC11

16q12.1

25

1382

NM033151

Drug resistance in breast cancer

ABCC12

16q12.1

25

1359

NM033226

Multidrug resistance

ABCC13

21q11.2

6

325

NM00387

Encodes a polypeptide of unknown function

ABCD1

Xq28

9

745

NM000033

Very-long-chain fatty acid (VLCFA) transport

ABCD2

12q11-q12

10

740

NM005164

Major modifier locus for clinical diversity in X-linked ALD (X-ALD)

ABCD3

1p22-p21

16

659

NM002858

Involved in import of fatty acids and/or fatty acyl-coenzyme As into the peroxisome

ABCD4

14q24

19

606

NM005050

May modify the ALD phenotype

ABCE1

4q31

14

599

NM002940

Oligoadenylate-binding protein

ABCF1

6p21.33

19

845

NM001025091

Susceptibility to autoimmune pancreatitis

ABCF2

7q36

14

634

NM005692

Tumour suppression at metastatic sites and in endocrine pathway for breast cancer/drug resistance

ABCF3

3q27.1

21

709

NM018358

Also present in promastigotes (one of five forms in the life cycle of trypanosomes)

ABCG1

21q22.3

13

678

NM004915

Cholesterol transport

ABCG2

4q22

16

655

NM004827

Toxicant efflux, drug resistance

ABCG4

q23.3

15

646

NM022 69

Found in macrophage, eye, brain and spleen

ABCG5

2p2

11

65

NM022436

Sterol transport

ABCG8

2p2

10

673

NM022437

Sterol transport