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Table S3 Results from simulations in which the relationship between FEV and confounders was modelled using the CAMP data, and phenotype data were truncated to exclude individuals with PPFEV ≤ 80 percent

From: Recommendations for using standardised phenotypes in genetic association studies

N Heritability Allele frequency Power in population-based design (%) Power in family-based design (%) Avg. R2 (%)
    FEV PPFEV FEV adj. PPFEV adj. FEV PPFEV FEV adj. PPFEV adj. FEV adj. PPFEV adj.
100 0.01 0.05 6.7 13.2 16.4 15.0 5.1 7.4 8.5 7.6 83.8 25.6
   0.1 6.5 12.5 15.4 14.1 5.6 7.4 8.8 8.1 83.8 25.5
   0.2 6.7 11.8 15.3 14.0 5.3 7.6 9.2 8.4 83.7 26.2
  0.025 0.05 9.4 24.2 32.8 29.1 6.3 11.6 14.6 13.2 83.5 25.5
   0.1 9.1 23.7 31.5 27.9 6.4 13.0 15.2 14.1 83.5 25.9
   0.2 8.8 22.0 29.9 26.3 6.9 12.7 15.5 14.0 83.4 26.3
  0.05 0.05 14.5 41.8 56.3 50.6 8.6 20.3 25.3 22.8 83.2 25.5
   0.1 13.7 40.4 54.6 48.3 8.2 21.5 27.2 24.0 83.1 25.9
   0.2 13.1 39.9 54.3 47.8 8.8 21.8 28.0 24.6 82.9 26.3
400 0.01 0.05 11.0 30.4 44.5 36.9 7.5 17.4 23.5 19.7 83.4 23.1
   0.1 11.2 31.0 44.1 37.1 7.7 18.1 24.0 20.8 83.4 23.3
   0.2 11.1 29.7 43.1 36.1 8.0 18.1 24.2 20.0 83.3 23.6
  0.025 0.05 21.8 63.4 83.2 73.9 13.2 38.1 51.4 44.5 83.2 23.1
   0.1 21.8 62.2 82.7 73.0 12.6 38.1 51.5 44.1 83.1 23.5
   0.2 20.6 61.9 81.6 72.0 12.9 36.2 50.7 42.9 83.0 23.8
  0.05 0.05 41.7 89.5 98.6 95.0 22.5 63.7 80.2 72.1 82.8 23.0
   0.1 39.4 88.9 98.6 94.7 21.0 63.7 80.5 72.3 82.7 23.3
   0.2 38.6 88.3 98.5 94.3 21.7 63.0 82.3 72.7 82.6 24.1
800 0.01 0.05 17.7 51.3 73.6 61.3 11.3 30.8 42.5 36.0 83.4 22.4
   0.1 16.6 50.7 72.2 60.3 11.3 30.1 43.7 35.7 83.3 22.6
   0.2 16.6 50.5 71.4 60.0 10.9 28.2 41.6 34.2 83.3 22.9
  0.025 0.05 38.3 87.4 98.4 93.3 20.7 63.5 80.8 71.2 83.1 22.5
   0.1 36.9 87.3 98.3 93.1 20.5 61.5 81.4 71.0 83.1 22.7
   0.2 36.2 86.6 98.2 92.8 20.0 61.2 81.6 70.8 82.9 23.2
  0.05 0.05 68.3 97.6 100.0 98.5 40.3 88.0 97.8 93.2 82.7 22.4
   0.1 67.0 97.7 100.0 98.6 39.0 88.6 98.6 94.0 82.6 22.8
   0.2 65.2 97.4 100.0 98.2 38.0 87.8 98.3 93.4 82.5 23.3
  1. FEV, forced expiratory volume; PPFEV, percentage of predicted FEV