Figure 2

Number of unrelated case-control samples needed, in addition to a fixed sample of either nuclear or extended pedigrees, to achieve a power of 92 per cent under an additive model (No Dom) and 86 per cent under a model with 50 per cent additive and 50 per cent dominance variance (Add = Dom). Values were generated for fixed sample sizes of both nuclear families and extended pedigrees, as well as for allele frequencies of both 0.5 and 0.1.