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Table 2 Summary of the significant HIF pathway candidate genes for the four test statistics used to detect signatures of positive selection

From: Identifying positive selection candidate loci for high-altitude adaptation in Andean populations

 

Test for natural selection

 

Gene

name

LSBL

lnRH

Tajima's D

Difference

WGLRH

ADRA1B

X

   

ARNT2

X

   

ATP1A1

 

X

  

ATP1A2

X

   

CDH1

X

X

  

COPS5

X

   

CXCR4

X

   

EDN1

X

   

EDNRA

X

X

X

 

EGLN1

X

   

EGLN2

X

   

ELF2

X

X

  

FRAP1

 

X

  

IL1A/

 

X

  

IL1B

    

IL6

X

   

IGFBP1

  

X

 

IGFBP2

X

   

MDM2

X

   

MMP2

X

   

NOS1

X

   

NOS2A

X

X

X

 

NOTCH1

X

   

NRP1

  

X

 

NRP2

X

   

POLRA

 

X

  

PIK3CA

X

 

X

 

PIK3CG

  

X

 

PRKAA1

X

X

X

 

PRKAA2

X

   

SNAI3

X

   

SPRY2

X

   

TF

X

   

TGFA

X

   

TNC

X

X

  

TNF

X

   

VEGF

X

 

X

 
  1. LSBL = locus-specific branch length; lnRH = natural log of the ratio of heterozygosities; WGLRH = whole-genome long-range haplotype.
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Human Genomics

ISSN: 1479-7364