Table 1 Polymorphic genes covered on the CYP-allele website
Gene | No. alleles | Important variant alleles | Examples of substrates |
|---|---|---|---|
CYP1A1 | 11 | None | Benzo(a)pyrene |
CYP1A2 | 16 | CYP1A2*1F, CYP1A2*1K | Clozapine |
CYP1B1 | 26 | Many rare detrimental variants | Oestradiol |
CYP2A6 | 37 | CYP2A6*4 | Nicotine |
CYP2A13 | 9 | CYP2A13*2 | N-nitrosomethylphenylamine |
CYP2B6 | 29 | CYP2B6*6 | Efavirenz |
CYP2C8 | 14 | CYP2C8*3 | Paclitaxel |
CYP2C9 | 34 | CYP2C9*2, *3 | Warfarin |
CYP2C19 | 26 | CYP2C19*2, *3, *17 | Escitalopram |
CYP2D6 | 78 | CYP2D6*4, *2xn | Tricyclic antidepressants |
CYP2E1 | 7 | None | Ethanol, carbon tetrachloride |
CYP2F1 | 6 | CYP2F1*2A | 3-methylindole |
CYP2J2 | 10 | CYP2J2*2-5 | Arachidonic acid, some drugs |
CYP2R1 | 2 | CYP2R1*2 | Vitamin D25 |
CYP2S1 | 5 | CYP2S1*3 | Orphan enzyme |
CYP2W1 | 6 | CYP2W1*6 | Indoles |
CYP3A4 | 20 | CYP3A4*1B | Clinically used drugs |
CYP3A5 | 11 | CYP3A5*3 | Cyclophosphamide |
CYP3A7 | 3 | CYP3A7*2 | Clinically used drugs |
CYP3A43 | 3 | None | None |
CYP4A11 | None | Only single SNPs | Arachidonic acid |
CYP4A22 | 15 | Not known | Orphan enzyme |
CYP4B1 | 7 | Not known | Lauric acid |
CYP4F2 | 3 | CYP4F2*3 | Vitamin K1 |
CYP5A1 | 9 | Not known | Prostaglandin H2 |
CYP8A1 | 4 | Not known | Prostaglandin H2 |
CYP19A1 | 5 | CYP19A1*4, *5 | Androstenedione |
CYP21A2 | 119 | Several rare variants | Progesterone |
CYP26A1 | 4 | CYP26A1*3, *4 | Retinoic acid |
POR | 41 | POR*2, *3 | Electron donor to CYPs |