Figure 3
From: Evolutionary divergence and functions of the human acyl-CoA thioesterase gene (ACOT) family
Unrooted dendrogram of human acyl-CoA thioesterases (ACOTs). Phylogenetic tree created using ClustalW2 and edited using TreeIllustrator. ACHE and CES1 were included as distant homologues belonging to the α/β-hydrolase fold superfamily. Bile acid acetyl Co-A:amino acid N-acyltransferase (BAAT), thioesterase superfamily members 4 and 5 (THEM4 and THEM5) are the closest-related homologues to type I (BAAT) and type II sequences (THEM4 and THEM5). ACTB was included as an unrelated sequence used to ground the tree. Type I ACOT branches are highlighted in blue, whereas type II are in red. Abbreviations: ACHE, acetylcholinesterase; ACTB; β-actin; CES1, carboxylesterase 1