Figure 2
From: Transient receptor potential (TRP) gene superfamily encoding cation channels
The dendrogram of the TRP superfamily in humans. Random proteins bound to the plasma membrane (ie EGF receptor, EGFR), endoplasmic reticulum (ie calreticulin precursor, CP), mitochondria (thioredoxin reductase, TR), nuclear membrane (ie inner nuclear membrane protein, INMP) and a cystolic protein (ie mitogen-activated protein kinase 1, MAPK1) were selected to determine if PKD and MCOLN are evolutionarily related to TRP or the results of convergent evolution. Note that PKD and MCOLN belong to TRP superfamilies, since random genes extend from branches distinct from the TRP superfamily.