Table S1 Significantly enriched GO terms (Benjamini-corrected p-value <0.05) for human genes containing DMs identified as PCMs (listed in Table 4) against a background of known disease-causing genes. No significantly enriched GO terms were found to relate to biological processes or molecular function
GO Term | Category | Description | Fold enrichment | p-Value | Genes |
|---|---|---|---|---|---|
GO:0031224 | Cellular component | Intrinsic to membrane | 2.12 | 4.29E-03 | SLC5A1, DUOX2, CNGA3, ABCA4, SLC26A2, MFRP, ABCB4, IL12RB2, SLC26A4, IL12RB1, CRB1, SLC17A3, PKP2, NPHS1, RYR1, EXT1, SEZ6, ATP7B |
GO:0016021 | Cellular component | Integral to membrane | 2.21 | 4.59E-03 | SLC5A1, DUOX2, CNGA3, ABCA4, SLC26A2, MFRP, ABCB4, IL12RB2, SLC26A4, IL12RB1, CRB1, SLC17A3, PKP2, NPHS1, RYR1, EXT1, SEZ6, ATP7B |
GO:0005886 | Cellular component | Plasma membrane | 2.17 | 5.49E-03 | SLC5A1, DUOX2, ABCA4, SLC26A2, ABCB4, IL12RB2, SLC26A4, IL12RB1, ANK1, CRB1, SLC17A3, F5, PKP2, NPHS1, RYR1, SEZ6, ATP7B |
GO:0031226 | Cellular component | Intrinsic to plasma membrane | 3.02 | 3.92E-02 | IL12RB2, IL12RB1, SLC17A3, SLC5A1, NPHS1, RYR1, ABCA4, SLC26A2, ATP7B, ABCB4 |
GO:0005887 | Cellular component | Integral to plasma membrane | 3.11 | 3.93E-02 | IL12RB2, IL12RB1, SLC17A3, SLC5A1, NPHS1, RYR1, ABCA4, SLC26A2, ATP7B, ABCB4 |