|  |  | Expanded sibpair cohort | Greeks |  | NHS/HPFS | Meta-analysis | |||
---|---|---|---|---|---|---|---|---|---|---|
SNP | Gene | Allele | Odds ratio (95% CI) | p-Value | Odds ratio (95% CI) | p-Value | Odds ratio (95% CI) | p-Value | Odds ratio (95% CI) | p-Value |
rs2189480 | VDR | A | 1.801 (1.069-3.035) | 0.0270 | 1.199 (0.846-1.700) | 0.3080 | 0.903 (0.766-1.064) | 0.2213 | 0.997 (0.865-1.151) | 0.9710 |
rs2296241 | CYP24A1 | C | 1.345 (0.829-2.182) | 0.2294 | 1.185 (0.842-1.668) | 0.3306 | Â | Â | 1.036 (0.814-1.319) | 0.7711 |
rs4809960 | CYP24A1 | G | 0.983 (0.567-1.703) | 0.9515 | 1.027 (0.690-1.527) | 0.8967 | Â | Â | 1.116 (0.843-1.477) | 0.4425 |
rs4809959 | CYP24A1 | T | 1.238 (0.770-1.989) | 0.3781 | 1.058 (0.761-1.470) | 0.7369 | Â | Â | 1.124 (0.885-1.427) | 0.3391 |
rs2181874 | CYP24A1 | T | 0.871 (0.501-1.515) | 0.6242 | 0.687 (0.481-0.983) | 0.0400 | 0.989 (0.812-1.204) | 0.9116 | 0.894 (0.763-1.046) | 0.1629 |
rs6068816 | CYP24A1 | A | 2.081 (0.945-4.586) | 0.0690 | 1.141 (0.695-1.875) | 0.6012 | Â | Â | 1.243 (0.851-1.817) | 0.2600 |
rs6091828 | CYP24A1 | A | 1.338 (0.281-6.382) | 0.7148 | 0.536 (0.206-1.393) | 0.2006 | Â | Â | 0.745 (0.356-1.560) | 0.4352 |
rs6127119 | CYP24A1 | A | 1.284 (0.724-2.274) | 0.3924 | 1.245 (0.831-1.865) | 0.2881 | Â | Â | 1.257 (0.937-1.688) | 0.1275 |
c.990 + 189 G > A | CYP24A1 | A | 0.887 (0.138-5.700) | 0.8993 | 1.699 (0.323-8.925) | 0.5312 | Â | Â | 1.123 (0.347-3.630) | 0.8464 |
rs6127118 | CYP24A1 | T | 1.297 (0.725-2.319) | 0.3816 | 1.274 (0.845-1.921) | 0.2471 | 1.050 (0.864-1.276) | 0.6230 | 1.111 (0.946-1.305) | 0.1995 |
c.990 + 222- 223 ins99 | CYP24A1 | ins | 1.341 (0.744-2.417) | 0.3288 | 1.297 (0.867-1.939) | 0.2055 | 1.086 (0.874-1.350) | 0.4564 | 1.145 (0.963-1.363) | 0.1258 |
rs2296239 | CYP24A1 | A | 1.457 (0.819-2.590) | 0.2000 | 1.529 (0.976-2.396) | 0.0638 | 1.205 (0.993-1.463) | 0.0584 | 1.217 (1.035-1.430) | 0.0174 |
rs2274130 | CYP24A1 | C | 1.751 (0.975-3.147) | 0.0610 | 1.512 (0.970-2.358) | 0.0679 | 1.255 (1.029-1.529) | 0.0247 | 1.248 (1.059-1.47) | 0.0082 |
rs1570670 | CYP24A1 | C | 1.790 (0.981-3.267) | 0.0579 | 1.512 (0.970-2.358) | 0.0679 | 1.195 (0.984-1.452) | 0.0725 | 1.220 (1.037-1.436) | 0.0165 |
rs1977297 | CYP24A1 | A | 0.725 (0.293-1.791) | 0.4856 | 1.142 (0.621-2.101) | 0.6693 | Â | Â | 1.009 (0.643-1.582) | 0.9694 |
rs1570669 | CYP24A1 | C | 1.153 (0.690-1.927) | 0.5875 | 1.287 (0.894-1.852) | 0.1753 | 1.309 (1.104-1.551) | 0.0019 | 1.285 (1.116-1.478) | 0.0005 |
rs927650 | CYP24A1 | A | 0.914 (0.596-1.402) | 0.6804 | 1.468 (1.048-2.056) | 0.0257 | 0.853 (0.728-0.999) | 0.0487 | 0.969 (0.852-1.102) | 0.6316 |
rs2762934 | CYP24A1 | T | 0.743 (0.367-1.502) | 0.4082 | 1.067 (0.704-1.619) | 0.7595 | 0.930 (0.754-1.148) | 0.5016 | 0.949 (0.798-1.130) | 0.5574 |
rs4809957 | CYP24A1 | C | 1.475 (0.822-2.644) | 0.1925 | 1.462 (0.943-2.268) | 0.0896 | 1.191 (0.981-1.445) | 0.0772 | 1.196 (1.017-1.405) | 0.0300 |
rs6022987 | CYP24A1 | G | 0.755 (0.427-1.336) | 0.3347 | 1.169 (0.804-1.699) | 0.4136 | Â | Â | 1.109 (0.845-1.456) | 0.4567 |
rs11907350 | CYP24A1 | T | 0.363 (0.066-2.000) | 0.2445 | 1.296 (0.438-3.836) | 0.6397 | 1.246 (0.829-1.872) | 0.2896 | 1.111 (0.772-1.598) | 0.5711 |