Table 2 Mechanistic basis of the NF1 gene-associated LOH identified in different NF1-associated tumours
From: Neurofibromatosis type 1-associated tumours: Their somatic mutational spectrum and pathogenesis
Tumour type | Tumour showing mitotic recombination (number & percentile) | Tumours with genomic deletions (number & percentile) |
|---|---|---|
Dermal neurofibroma | 28 (76%) | 8 (24%) |
Plexiform neurofibroma | 11 (44%) | 14 (56%) |
Spinal neurofibroma | 7 (88%) | 1 (12%) |
MPNST | 5 (16%) | 26 (84%) |
Astrocytoma | 0 (0%) | 2 (100%) |
GIST/gastric carcinoid | 1 (50%) | 1 (50%) |
JMML | 15 (79%) | 4 (21%) |
Phaeochromocytoma | 0 (0%) | 0 (0%) |
Glomus tumour | 1 (100%) | 0 (0%) |