Strong interaction between T allele of endothelial nitric oxide synthase with B1 allele of cholesteryl ester transfer protein TaqIB highly elevates the risk of coronary artery disease and type 2 diabetes mellitus

Table 1 Demographic and biochemical parameters of the controls and patients

Parameters	CAD patients with and without diabetes (n = 207)	T2DM (n = 101)	Control subjects (n = 92)
Age (years)	56.9 ± 8.6*NS	56.5 ± 9.8	54.3 ± 8.5
Sex (M/F)	113/94*NS	51/50	47/45
FBS (mg/dl)	136.2 ± 59.6, p < 0.001	162.9 ± 71.3, p < 0.001	97.0 ± 20.1
History of hypertension (%)	102 (49.6), p < 0.001	29 (28.7), p = 0.68	24 (26.1)
LDL-C (mg/dl)	96 ± 28, p < 0.001	98.5 ± 38.4, p < 0.001	83 ± 18
HDL-C(mg/dl)	47 ± 9.3, p = 0.007	45.2 ± 10.2, p < 0.001	49.8 ± 5.8
TC (mg/dl)	186 ± 42, p = 0.046	185.9 ± 45.8, p = 0.09	177 ± 26
TG (mg/dl)	177 ± 89, p = 0.038	200.8 ± 99.3, p = 0.001	156 ± 48
BMI (kg/m²)	26 ± 2.7*NS	26.2 ± 2.7*NS	26.6 ± 3.7

Plasma fasting blood sugar (FBS), LDL-C, HDL-C, TC, and TG levels, as well as age and BMI were compared between patients and controls using two-tailed Student’s t test. The sex was compared between two groups by the χ²-test. NS, not significant; *p > 0.05.

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