New susceptibility locus for obesity and dyslipidaemia on chromosome 3q22.3

Table 1 Association of MRAS variants with coronary artery disease

Model	Unstandardized coefficient		Standardized coefficient	t	pvalue	95.0% C.I. for beta
	Beta	S.E.	Beta			Lower bound	Upper bound
Sex	−0.107	0.009	−0.102	−12.05	0.000***	−0.125	−0.09
Age	0.003	0.000	0.081	8.53	0.000***	0.002	0.003
FH	−0.004	0.01	−0.003	−0.401	0.689	−0.024	0.016
T2DM	0.082	0.009	0.082	9.034	0.000***	0.064	0.1
MI	0.586	0.01	0.56	59.874	0.000***	0.567	0.605
HTN	0.03	0.01	0.026	2.907	0.004***	0.01	0.05
OBS	−0.018	0.008	−0.018	−2.177	0.03*	−0.035	−0.002
rs119338_C	0.002	0.023	0.002	0.106	0.915	−0.043	0.048
rs166195_C	0.053	0.049	0.045	1.076	0.282	−0.044	0.15
rs166195_T	0.038	0.048	0.033	0.785	0.433	−0.057	0.133
rs253662_T	−0.012	0.019	−0.009	−0.622	0.534	−0.049	0.026
rs1720819_T	−0.182	0.052	−0.119	−3.505	0.000***	−0.284	−0.08
rs1720819_G	−0.164	0.055	−0.104	−2.996	0.003**	−0.272	−0.057
rs6782181_AA	0.073	0.031	0.071	2.379	0.017*	0.013	0.133
rs6782181_T	0.057	0.031	0.055	1.816	0.069	−0.005	0.118
rs3732837_AA	0.013	0.022	0.009	0.58	0.562	−0.03	0.056
rs3732837_T	−0.027	0.043	−0.017	−0.643	0.52	−0.111	0.056
rs9818870_C	0.097	0.04	0.063	2.416	0.016*	0.018	0.176
rs9818870_T	0.14	0.054	0.087	2.612	0.009**	0.035	0.246

The table shows the significant association of the MRAS gene variants with CAD following Bonferroni correction. Beta, odds ratio coefficient; FH family history of CAD, T2DM type 2 diabetes mellitus, MI myocardial infarction, HTN hypertension, OBS obesity, C.I confidence interval, S.E. standard error; t, standard t test. *p < 0.05; **p < 0.01; ***p < 0.005.

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