New susceptibility locus for obesity and dyslipidaemia on chromosome 3q22.3

Table 2 Association of MRAS gene with obesity and dyslipidaemia

Variant	Controls	Cases	Univariate analysis		Multivariate analysis
Variant	Controls	Cases	Exp( B) (95% C.I.)	pvalue	Exp( B) (95% C.I.)	pvalue
Obesity
rs6782181_GG	0.153	0.397	1.15(1.02–1.29)	0.023*	1.16(1.03–1.30)	0.017*
Hypercholesterolaemia
rs253662_TT	0.051	0.038	0.73(0.59–0.90)	0.041*	0.74(0.53–1.01)	0.054
rs6782181_GG	0.015	0.022	1.47(1.07–2.03)	0.018*	1.23(1.02–1.47)	0.019*
Low HDL levels
rs166195_CT+TT	0.356	0.385	1.14(1.00–1.29)	0.047*	1.00(0.99–1.00)	0.961
rs253662_CT+TT	0.318	0.344	1.13(0.99–1.29)	0.064	1.16(1.01–1.32)	0.030*
rs6782181_GG	0.151	0.167	1.13(1.00–1.27)	0.045*	1.15(1.02–1.30)	0.023*
High LDL-cholesterol
rs253662_T	0.192	0.162	0.82(0.70–0.96)	0.013*	0.82(0.69–0.96)	0.014*
rs253662_CT+TT	0.336	0.291	0.82(0.67–0.98)	0.028*	0.81(0.68–0.98)	0.030*
rs6782181_G	0.387	0.356	0.88(0.77–0.99)	0.038*	0.88(0.77–0.99)	0.040*
rs6782181_AG+GG	0.614	0.564	0.82(0.68–0.97	0.019*	0.81(0.68–0.97)	0.019*
Hypertriglyceridaemia
rs6782181_G	0.152	0.175	1.19(1.00–1.42)	0.067	1.29(1.01–1.45)	0.043*

The table shows the MRAS variants associated with the disease traits. B, odds ratio; C.I., confidence interval. *p < 0.05.

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