Rank-based genome-wide analysis reveals the association of Ryanodine receptor-2 gene variants with childhood asthma among human populations

Table 7 Population genetic differentiation and population differences in genetic association with asthma

Allele frequencies in CAMP and CARE	F _ST			DRP > mean (DRP) and F_ST > mean (F_ST)
	Mean	Median	Range	Observed	Expected	pvalues^a
From parents
Caucasian vs. African-American	0.0463	0.0263	(0, 0.5858)	108,245	107,720	0.007898
Caucasian vs. Hispanic	0.0078	0.0036	(0, 0.1770)	95,757	94,447	7.749 × 10⁻¹²
African-American vs. Hispanic	0.0387	0.0215	(0, 0.4989)	107,740	107,384	0.07227
From the affected offspring
Caucasian vs. African-American	0.0487	0.0274	(0, 0.6036)	107,987	107,432	0.004965
Caucasian vs. Hispanic	0.0114	0.0050	(0, 0.2226)	98,522	97,445	2.39 × 10⁻⁸
African-American vs. Hispanic	0.0433	0.0238	(0, 0.5429)	107,458	107,225	0.2408

^ap values of the chi-square test of the frequency table of DRP > mean (DRP) and F_ST > mean (F_ST). DRP, difference between the rankings of p values in the two populations.

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