Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models

Table 4 Testing in the Atp1a2 heterozygous mice

Test	Phenotype measured	Parameters measured	Heterozygous compared with wild type	Lab
Hidden platform	Learning and memory	Latency time	Decreased	Lingrel
Elevated zero maze	Anxiety	Time spent in open arms	Decreased	Lingrel
Elevated zero maze	Anxiety	Entries into open quadrant	Decreased
Open-field activity	Anxiety	Time spent in corners	Increased	Lingrel
Open-field activity	Anxiety	Total distance traveled	Decreased	Lingrel and Kawakami
Light/dark	Anxiety	Path length in light compartment	Decreased	Kawakami
		Time spent in light compartment	Decreased
		Latency to first entry into light compartment	Increased
		Number of transitions between light and dark	Decreased
Elevated plus maze	Anxiety	Time in open arms	Decreased	Kawakami
Elevated plus maze	Anxiety	Entries into open arms	Decreased
Conditioned fear stimuli	Fear and learning	Freezing time	Increased	Kawakami
Cardiac performance	Hypercontractile heart	Contractibility	Increased	Lingrel

The various tests, parameter measured, and results were compared with the wild type [17, 18].

ISSN: 1479-7364