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Table 1 List of age-dependent differentially expressed genes

From: Novel age-dependent targets in vestibular schwannomas

Gene symbol

Fold change

pvalue

Function

Activity

Role in cancer

ANLN

3.55

0.0053

 

Actin-binding protein

Overexpressed in pancreatic carcinoma

NAV3

1.65

0.0099

G

Neuron growth, regeneration

Neural tumorigenesis

ZNF718

1.61

0.0064

 

Zinc finger protein

Associated with prostate cancer

PSCD3

1.59

0.0035

T

Protein sorting and membrane trafficking

 

C180rf54

1.57

0.0047

  

Overexpressed in multiple cancers

XPO1

1.56

0.0079

T/K

Nuclear protein transport export

 

C10rf79

1.56

0.0065

   

GMNN

1.55

0.0032

G

Proliferation marker

Correlated with poorer clinical outcome

WHSC1

1.51

0.006

 

Regulation of Wnt pathway

Expression increases with ascending glioma proliferation activity

EPHA2

1.51

0.0073

K

Tyrosine Kinase

Overexpressed in many types of cancer

SNF1LK2

-2.03

0.0055

K

Serine/Threonine kinase

Correlated with ovarian cancer poor survival

NGFRAP1L1 (BEX5)

-1.8

0.0009

G

Nerve growth factor receptor-associated

May be a tumor suppressor in VS

ELL2

-1.8

0.0031

 

Suppress canonical Wnt signaling

ELL translocations in malignancies.

SYTL3

-1.79

0.0053

T

Vesicular trafficking

 

KCNK17

-1.76

0.006

 

Potassium channel

Expressed abnormally in many cancer types

IGLV1-44

-1.68

0.0057

   

PID1

-1.62

0.0084

 

Glucose transport inhibitor

 

RGN

-1.59

0.0052

 

Suppresses cell proliferation

Lost in breast and prostate cancer

PTPN1

-1.57

0.0076

K/G

Cell growth

 

ZNF331

-1.53

0.0074

D

Induces apoptosis

 

RNF19A

-1.52

0.0025

D

Neuronal cell death

 
  1. T transport, K kinase, G growth, D death.