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Figure 6 | Human Genomics

Figure 6

From: Forced swim test induces divergent global transcriptomic alterations in the hippocampus of high versus low novelty-seeker rats

Figure 6

ER stress and eIF2a pathways appear to be induced in the hippocampus of HR rats. Induction of these pathways could be implicated in the mobilization of apoptotic mechanisms in hippocampal neurons of HR rats upon FST exposure. Upregulated genes are shown in red. Blind lines denote binding, arrows signify activation, whereas T-like lines indicate inhibition. ATF-6 activation transcription factor 6, eIF2a eukaryotic initiation factor 2a, eIF2b eukaryotic initiation factor 2b, Gsk3b glycogen synthase kinase-3 beta, Ido1 indoleamino-2,3-dioxygenase, MBTPS membrane-bound transcription factor peptidase, Perk eIF2a kinase 3, Sgpp2 sphingosine-1-phosphate (S1P) phosphatase 2, Ripk1 TNF receptor (TNFRSF)-interacting serine-threonine kinase 1, TNFR1 tumor necrosis factor receptor superfamily.

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Human Genomics

ISSN: 1479-7364