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Figure 7 | Human Genomics

Figure 7

From: A gene-specific non-enhancer sequence is critical for expression from the promoter of the small heat shock protein gene αB-crystallin

Figure 7

Hypothetical schemes of GPS involvement in regulating cryab promoter activity. The schematics shown are based on the observation that cryab promoter cannot function without the GPS. Without the GPS, the interaction of the HSF4 with the HSE is weak (indicated by monomeric interaction of HSF with HSE) and therefore non-productive (red X) ( A ). GPS presence could simply enhance binding of HSF4 to the HSE by itself ( B ) or by binding to another transacting factor that could be a protein ( C ) or an RNA ( D ). On the other hand, GPS could act as a chromosomal landmark for the open promoter. This may involve protein-DNA as well as protein-protein interactions ( E ) that would facilitate HSF4 binding to the HSE as well as opening of the promoter for transcriptional activity. We do not know what comes first: the involvement of the GPS, or the binding of HSF4 in the events that lead to the activation of the cryab promoter? The data presented in this investigation suggests that the involvement of the GPS must precede any event(s) that leads to cryab promoter activation.

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Human Genomics

ISSN: 1479-7364