Table 1 Oligonucleotides used in site- directed mutagenesis

1

Sense: 5'-GCTCAGCCCAGCGAAATTTCAGCCTCTGCCCAGG-3'

Figure 2A/number 2

Antisense: 5'-CCTGGGCAGAGGCTGAAATTTCGCTGGGCTGAGC-3'

2

Sense: 5'-CCCTGACATCACCATTACACGATCTTTACAAGACTGCATATA-3'

Figure 2A/number 3

Antisense: 5'-TATATGCAGTCTTGTAAAGATCGTGTAATGGTGATGTCAGGG-3'

3

Sense: 5'-ATAATAAAACCCCCAGTGCTGTTGTTCCAGAAGCTTCACAAGAC-3'

Figure 2A/number 5

Antisense: 5'-GTCTTGTGAAGCTTCTGGAACAACAGCACTGGGGGTTTTATTAT-3'

4

Sense: 5'-CGAGCTCAAGCTTCGAATTCCAGTGCTGTTGTTCCAGAAGCTTCAC-3'

Figure 2A/number 9

Antisense: 5'-GTGAAGCTTCTGGAACAACAGCACTGGAATTCGAAGCTTGAGCTCG-3'

5

Sense: 5'-CCGTTCCAGAAGCTTCACAAGCCTGCATATATAAGGGGC-3'

Figure 2B/number 2

Antisense: 5'-GCCCCTTATATATGCAGGCTTGTGAAGCTTCTGGAACGG-3'

6

Sense: 5'-CCGTTCCAGAAGCTTCAACCGACTGCATATATAAGGGGCAGGC-3'

Figure 2B/number 3

Antisense: 5'-GCCTGCCCCTTATATATGCAGTCGGTTGAAGCTTCTGGAACGG-3'

7

Sense: 5'-CCTGACATCACCGTTCCAGAAGCTTCACTGCATATATAAGGGGCAGGCTG-3'

Figure 2B/number 4

Antisense: 5'-CAGCCTGCCCCTTATATATGCAGTGAAGCTTCTGGAACGGTGATGTCAGG-3'

8

Sense: 5'-GCTGGGATAATAAAACCCCGGTGATGTCAGTTCCAGAAGCTTCACAAG-3'

Figure 3A/number 3

Antisense: 5'-CTTGTGAAGCTTCTGGAACTGACATCACCGGGGTTTTATTATCCCAGC-3'

9

Sense: 5'-GCTGGGATAATAAAACCCCCCACTACAGTGTTCCAGAAGCTTCACAAG-3'

Figure 3A/number 4

Antisense: 5′-CTTGTGAAGCTTCTGGAACACTGTAGTGGGGGGTTTTATTATCCCAGC-3'

10

Sense: 5'-CCAGAAGCTTCACAAGATGACATCACCCTGCATATATAAGGGGC-3'

Figure 3A/number 5

Antisense: 5'-GCCCCTTATATATGCAGGGTGATGTCATCTTGTGAAGCTTCTGG-3'

11

Sense: 5'-GGGATAATAAAACCCCGTTCCAGAAGCTTCAC-3'

Figure 3B/number 2

Antisense: 5'-GTGAAGCTTCTGGAACGGGGTTTTATTATCCC-3'

12

Sense: 5'-GACACCTAGTTCTGACATGACATCACCTATTGGTGGTCACAGCTCTCC-3'

Figure 3B/number 3

Antisense: 5'-GGAGAGCTGTGACCACCAATAGGTGATGTCATGTCAGAACTAGGTGTC-3'

13

Sense: 3'-CCCTGGGGCTCAGCCCATGACATCACCGGAAGATTCCAGCCTCTGCC-3'

Figure 3B/number 4

Antisense: 5'-GGCAGAGGCTGGAATCTTCCGGTGATGTCATGGGCTGAGCCCCAGGG-3'

14

Sense: 5'-CTGGCTCCAGAGAACAAGTGACATCACCGATGGGGTGGGTGGGTGCC-3'

Figure 3B/number 5

Antisense: 5'-GGCACCCACCCACCCCATCGGTGATGTCACTTGTTCTCTGGAGCCAG-3'

15

Sense: 5'-CTTTTCTTAGCTCAGTGAGTGACATCACCTACTGGGTATGTGTCACC-3'

Figure 3B/number 6

Antisense: 5'-GGTGACACATACCCAGTAGGTGATGTCACTCACTGAGCTAAGAAAAG-3'

16

Sense: 5'-GGGGAGCTGGGATAATAATGACATCACCAACCCCGTTCCAGAAGC-3'

Figure 3B/number 7

Antisense: 5'-GCTTCTGGAACGGGGTTGGTGATGTCATTATTATCCCAGCTCCCC-3'

17

Sense: 5'-CCCCTGACATCACCCAAGACTGCATATATAAGGGG-3'

Figure 4/number 5

Antisense: 5'-CCCCTTATATATGCAGTCTTGGGTGATGTCAGGGG-3'

18

Sense: 5'-GCTGGGATAATAAAACCCCCAAGACTGCATATATAAGGGGC-3'

Figure 4/number 6

Antisense: 5'-GCCCCTTATATATGCAGTCTTGGGGGTTTTATTATCCCAGC-3'