Figure 1

Illustration of an integrated systems biology approach to improve drug therapy. Using phenomics to fully characterize clinical traits associated with drug therapy. When combined with metabolomics, common biological pathways can be identified, providing insight into mechanisms of efficacy and safety. When phenomic data associated with genomics data are also combined, pleiotropic associations can be further identified and contribute to our understanding of underlying biological pathways. Other techniques, such as RNA-seq, can be integrated to add depth to the pathway data and supplement our understanding of genomic expression.