Table 6 The pathways associated to cancer
Pathway name | p value | Number of genes | Genes | Number of variants | Tumour tissue | Control tissue |
|---|---|---|---|---|---|---|
CD-SNVs | ||||||
Wnt/β-catenin signalling | 7.07E-04 | 6 | CREBBP, RARA, SMO, SOX10, SOX7, TCF3 | 6 | 1 | 0 |
Epithelial adherens junction Ssignalling | 1.26E-02 | 4 | IQGAP1, KEAP1, TCF3, TUBG1 | 4 | 1 | 0 |
Germ cell-sertoli cell junction signalling | 2.10E-02 | 4 | GSN, IQGAP1, KEAP1, TUBG1 | 5 | 1 | 0 |
Mouse embryonic stem cell pluripotency | 2.59E-02 | 3 | CREBBP, SMO, TCF3 | 3 | 1 | 0 |
Regulation of the epithelial-mesenchymal transition pathway | 3.40E-02 | 4 | FGFR2, SMO, TCF3, ZEB2 | 4 | 1 | 0 |
Hereditary breast cancer signalling | 4.95E-02 | 3 | CREBBP, NPM1, TUBG1 | 3 | 1 | 0 |
Small indels | ||||||
IL-17A signalling in gastric cells | 8.79E-03 | 1 | RELA | 1 | 1 | 0 |
Role of JAK1, JAK2 and TYK2 in interferon signalling | 9.54E-03 | 1 | RELA | 1 | 1 | 0 |
Interferon signalling | 9.79E-03 | 1 | RELA | 1 | 1 | 0 |
IL-15 production | 1.00E-02 | 1 | RELA | 1 | 1 | 0 |
TNFR2 signalling | 1.05E-02 | 1 | RELA | 1 | 1 | 0 |
RANK signalling in osteoclasts | 2.86E-02 | 1 | RELA | 1 | 1 | 0 |