Study population | Specific phenotype | Study subjects ( n ) | Ancestry type | Markers ( n ) | Main findings | Reference |
---|---|---|---|---|---|---|
AA | Lung function | 2,169 | Structure | Variable | Increasing Af ancestry associated with lower FEV1 and lower FVC | Kumar et al. [38] |
AA | Asthma, exacerbation | 392 | Structure | 59 | Increasing Af ancestry associated with increasingly severe asthma exacerbation in males but not females | Rumpel et al. [64] |
AA | Smoking/lung function interaction | 1,281 | Structure | 1,332 | Increasing Af ancestry associated with lower FEV1 per pack-year of smoking | Aldrich et al. [63] |
LA | Asthma severity | 362 | IBGA | 44 | Increasing NA ancestry associated with less severe asthma | Salari et al. [56] |
Puerto Ricans | Lung function | 416 | LAMP | 85,059 | Increasing Af ancestry associated with decreased FEV1 and FVC pre- and post-bronchodilator | Brehm et al. [19] |