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Table 2 Studies considering the relationship between degrees of ancestry proportion and asthma and asthma-related outcomes

From: Self-reported race/ethnicity in the age of genomic research: its potential impact on understanding health disparities

Study population Specific phenotype Study subjects ( n ) Ancestry type Markers ( n ) Main findings Reference
AA Lung function 2,169 Structure Variable Increasing Af ancestry associated with lower FEV1 and lower FVC Kumar et al. [38]
AA Asthma, exacerbation 392 Structure 59 Increasing Af ancestry associated with increasingly severe asthma exacerbation in males but not females Rumpel et al. [64]
AA Smoking/lung function interaction 1,281 Structure 1,332 Increasing Af ancestry associated with lower FEV1 per pack-year of smoking Aldrich et al. [63]
LA Asthma severity 362 IBGA 44 Increasing NA ancestry associated with less severe asthma Salari et al. [56]
Puerto Ricans Lung function 416 LAMP 85,059 Increasing Af ancestry associated with decreased FEV1 and FVC pre- and post-bronchodilator Brehm et al. [19]
  1. Modified from Goetz et al. [62]. The structure is model-based clustering method; IBGA is a maximum likelihood-based clustering method, and LAMP is a local ancestry in admixed population inference method.
  2. Af African, Am Amerindian, As Asian, E European, NA Native American, AA African American, LA Latino American, FEV1 forced expiratory volume in 1 s, FVC forced vital capacity.