Table 1 The DM (disease-causing mutations) and DM? (putative disease-causing mutations but where there is some residual doubt as to pathological significance) mutations identified in each family
| Â | Cancer type | HGMD tag |
|---|---|---|
Family A, annotated variants | Â | Â |
 dbsnp.129:rs56250729 | Prostate cancer | DM? |
 dbsnp.125:rs28756990 | Endometrial cancer | DM? |
 dbsnp.131:rs77067228 | Cancer | DM? |
 dbsnp.89:rs1799966 | Breast and/or ovarian cancer | DM/DM? |
 dbsnp.113:rs4986852 | Breast cancer | DM? |
 COSMIC:mut:148278;dbsnp.86:rs799917 | Breast and/or ovarian cancer | DM |
 dbsnp.89:rs1799950 | Breast cancer | DM |
 dbsnp.98:rs2229995 | Adenomatous polyposis coli | DM? |
 dbsnp.127:rs41545019 | Colorectal cancer | DM? |
 dbsnp.98:rs1805324 | Colorectal cancer, non-polyposis | DM? |
 dbsnp.129:rs61753720 | Acute lymphoblastic leukemia | DM |
Family B, Annotated variants | Â | Â |
 dbsnp.126:rs33927012 | Medullary thyroid carcinoma | DM? |
 dbsnp.98:rs2229992 | Adenomatous polyposis coli | DM |
 dbsnp.76:rs41115 | Adenomatous polyposis coli | DM |
 dbsnp.79:rs169547 | Breast cancer | DM? |
 dbsnp.103:rs3092994 | Breast cancer | DM? |
 dbsnp.89:rs1799966 | Breast cancer | DM |
 dbsnp.86:rs1060915 | Breast cancer | DM |
 dbsnp.125:rs28897689 | Breast and/or ovarian cancer | DM |
 COSMIC:mut:148278;dbsnp.86:rs799917 | Breast and/or ovarian cancer | DM |
 dbsnp.60:rs16940 | Breast cancer | DM |