Fig. 3From: The clinical trial landscape in oncology and connectivity of somatic mutational profiles to targeted therapiesAutomated variant mapping process. The genomic datasets are transformed to standard Human Genome Variation Society (HGVS) nomenclature, using a standardized Regular Expressions (regex) vocabulary incorporated into the JAX-CKB. This enables mapping and identification of clinically meaningful variants in a scalable and reproducible manner. The variant mapping program also includes several filtering steps, including removal of low-impact variants, those that did not pass metrics, and those that are likely germline or false-positive, to ensure reporting of only high-quality somatic variationsBack to article page