Table 3 A list of SNPs associated with CHD in the subgroup tests
From: Association of six CpG-SNPs in the inflammation-related genes with coronary heart disease
Gene | SNP | Model or subgroup | Group | Genotype or allele (counts) | χ 2 | P (df) | OR (95 % CI) |
|---|---|---|---|---|---|---|---|
IL1B | rs16944 | Dominant | Cases | GG/GA + AA (220/556) | 4.350 | 0.037 (1) | 1.279 (1.015–1.611) |
|  |  |  | Controls | GG/GA + AA (173/559) |  |  |  |
IL1B | rs16944 | ≤55 years of age | Cases | G/A (236/236) | 6.190 | 0.013 (1) | 1.422 (1.077–1.877) |
| Â | Â | Â | Controls | G/A (292/248) | Â | Â | Â |
IL1B | rs16944 | 55–65 years of age | Cases | GG/GA/AA (79/134/57) | 6.147 | 0.046 (2) |  |
| Â | Â | Â | Controls | GG/GA/AA (53/145/66) | Â | Â | Â |
IL1B | rs16944 | 55–65 years of age | Cases | G/A (292/248) | 4.560 | 0.033 (1) | 1.299 (1.022–1.653) |
| Â | Â | Â | Cases | G/A (251/277) | Â | Â | Â |
IL1R2 | rs2071008 | ≤55 years of age | Controls | G/T (254/106) | 3.860 | 0.049 (1) | 0.733 (0.538–1.000) |
| Â | Â | Â | Cases | G/T (366/112) | Â | Â | Â |
PLA2G7 | rs9395208 | Dominant | Cases | GG/GC + CC (565/219) | 4.590 | 0.032 (1) | 0.777 (0.616–0.979) |
|  |  |  | Controls | GG/GC + CC (568/171) |  |  |  |
PLA2G7 | rs9395208 | ≤55 years of age | Cases | G/C (295/65) | 5.750 | 0.016 (1) | 0.627 (0.427–0.920) |
| Â | Â | Â | Controls | G/C (420/58) | Â | Â | Â |
FAM5C | rs12732361 | Male | Cases | G/C (849/225) | 4.660 | 0.031 (1) | 1.266 (1.022–1.568) |
| Â | Â | Â | Controls | G/C (629/211) | Â | Â | Â |
CD40 | rs1800686 | Female | Cases | G/A (354/138) | 5.230 | 0.022 (1) | 1.347 (1.043–1.740) |
| Â | Â | Â | Controls | G/A (417/219) | Â | Â | Â |
CD40 | rs1800686 | Dominant | Cases | GG/GA + AA (378/406) | 4.340 | 0.037 (1) | 1.239 (1.013–1.517) |
|  |  |  | Controls | GG/GA + AA (317/422) |  |  |  |
CD40 | rs1800686 | ≥65 years of age | Cases | GG/GA/AA (163/146/24) | 9.437 | 0.009 (2) |  |
| Â | Â | Â | Controls | GG/GA/AA (90/109/32) | Â | Â | Â |
CD40 | rs1800686 | ≥65 years of age | Cases | G/A (472/194) | 8.600 | 0.0034 (1) | 1.456 (1.132–1.874) |
| Â | Â | Â | Controls | G/A (289/173) | Â | Â | Â |
CD36 | rs2065666 | Male | Cases | G/C (790/286) | 4.000 | 0.046 (1) | 0.806 (0.652–0.996) |
| Â | Â | Â | Controls | G/C (641/187) | Â | Â | Â |