Table 4 The best three-way models identified by QMDR for COPD-related quantitative traits in Chinese Han population (n = 310 patients)

FEV₁

rs4147581(GSTP1)*rs2292568(EPHX1)*rs4674843(SERPINE2)

0.9948

3/10

NS

FEV₁%pre

rs282254(SERPINE2)*rs6738983(SERPINE2)*rs2241713(TGFB1)

0.4451

3/10

NS

FVC

rs2241715(TGFB1)*rs282254(SERPINE2)*rs6738983(SERPINE2)

−0.2469

2/10

NS

FEV₁/FVC (%)

rs10191694(SERPINE2)*rs282254(SERPINE2)*rs2241713(TGFB1)

0.0393

4/10

NS

BODE

rs13392495(SERPINE2)*rs2118409(SERPINE2)*rs2234922(EPHX1)

−0.1974

2/10

NS

MMRC

rs4147581(GSTP1)*rs2241718(TGFB1)*rs2118409(SERPINE2)

−2.3572

2/10

0.022*

6MWT

rs4674841(SERPINE2)*rs7583463(SERPINE2)*rs947895(GSTP1)

0.9901

2/10

NS