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Fig. 2 | Human Genomics

Fig. 2

From: Transcriptome sequencing of gingival biopsies from chronic periodontitis patients reveals novel gene expression and splicing patterns

Fig. 2

Differential alternative splicing of FN1 and BCL2A1. a In the left panel, a read distribution plot for FN1 with differential isoform expression due to the inclusion of EDB domain in periodontitis tissues was shown. The black boxes in the annotated isoforms illustrated below the read distributions indicate the exons. Arrows indicated the location of EDB exon, which was magnified in the dotted box in the upper right panel. In the lower right panel, a reverse transcription-PCR analysis was performed to detect included EDB exon. b A read distribution plot for BCL2A1 with differential isoform expression due to the skipping of exon 2 (arrows) in periodontitis tissues was shown in the left panel. In the right panel, a reverse transcription-PCR analysis was performed to detect skipped exon 2. M molecular weight marker, H healthy gingival tissues, and P periodontitis-affected gingival tissues

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Human Genomics

ISSN: 1479-7364