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Fig. 1 | Human Genomics

Fig. 1

From: A genomic case study of desmoplastic small round cell tumor: comprehensive analysis reveals insights into potential therapeutic targets and development of a monitoring tool for a rare and aggressive disease

Fig. 1

Network analysis by IPA. a Interaction network of genes harboring protein-affecting somatic mutations (network score = 45) is associated with the top disease and functions: cell death and survival, nervous system development and function, cellular compromise. b Interaction network of genes harboring rare polymorphisms detected in homozygosis in the patient (network score = 12) is associated with the top disease and functions: cell cycle, digestive system development and function, hair and skin development and function. c Interaction network of genes affected by compound heterozygous variants (network score = 25) is associated with the top disease and functions: cancer, organismal injury, abnormalities, and gastrointestinal disease. Continuous and dashed lines indicate direct and indirect interactions between molecules, respectively. Blue molecules represent the genes encountered in our analysis and blank molecules represent other genes automatically included by IPA. Molecules are displayed by various shapes depending on the functional class of the gene product, according to IPA Path designer shapes (Additional file 7)

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Human Genomics

ISSN: 1479-7364