Table 2 List of tag-SNPs, chromosomal location, SNP identifier number, chromosomal position, location in or near gene, ancestral gene, reference/alternative alleles, alternative allele frequency q(alt) in Caucasian (EUR) and African (AFR) populations from the 1000 Genomes Project, and q(alt) in cohort studied

1

AHR

7

rs62444550

17290494

−8128C > A, promoter

A

C/A

0.4264

0.6407

0.4265

2

AHR

7

rs77821156

17291826

−6796A > G, promoter

A

A/G

0.0815

0.0045

0.0900

3

AHR

7

rs10250822

17293365

−5257 T > C, promoter

T

T/C

0.2217

0.0908

0.2370

4

AHR

7

rs4719497

17295275

−3347 T > C, promoter

T

T/C

0.1243

0.0083

0.1374

5

AHR

7

rs3757824

17296411

−2211 T > C, promoter

T

T/C

0.2127

0.1490

0.1706

6

AHR

7

rs7796976

17298806

+185G > A, 5′-UTR, exon 1

G

G/A

0.2217

0.0840

0.00

7

AHR

7

rs713150

17300533

+1912C > G, intron 1

C

C/G

0.2177

0.1354

0.2322

8

AHR

7

rs17722841

17303970

+5349G > A, intron 1

G

G/A

0.1690

0.0061

0.1919

9

AHR

7

rs2282885

17305990

+7369A > G, intron 1

A

A/G

0.3956

0.0189

0.3697

10

AHR

7

rs2282883

17316723

+18102C > T, intron 2

T

C/T

0.3469

0.6293

0.3720

11

AHR

7

rs4236290

17323944

+253233 T > C, intron 3

T

T/C

0.1064

0.0061

0.1114

12

AHR

7

rs2158041

17328796

+30175C > T, intron 4

C

C/T

0.2187

0.0340

0.2322

13

AHR

7

rs3802082

17330557

+31936A > T, intron 5

A

A/T

0.1769

0.1513

0.1374

14

AHR

7

rs7811989

17331739

+33118G > A, intron 6

G

G/A

0.2396

0.1135

0.2749

15

AHR

7

rs2074113

17334147

+35526G > T, intron 7

G

G/T

0.1043

0.1520

0.0711

16

AHR

7

rs2066853

17339486

+40865G > A, exon 10, R554K

A

G/A

0.1083

0.4622

0.0995

1

CYP1A1

15 (rev)

rs4646903

74719300

CYP1A1*2A, Msp I RFLP Site, +6311A > G, downstream 3′

A

A/G

0.1074

0.2345

0.1066

2

CYP1A1

15 (rev)

rs2606345

74724835

+776A > C, intron 1

C

A/C

0.3370

0.9501

0.3768

3

CYP1A1

15 (rev)

rs3826042

74726564

−954C > T, promoter

C

C/T

0.0417

0.0053

0.0498

4

CYP1A1

15 (rev)

rs7495708

74727502

−1892 T > C, promoter

C

T/C

0.1541

0.5696

0.1919

1

CYP1A2

15

rs2069514

74745879

CYP1A2*1C, −2965G > A, promoter

G

G/A

0.0199

0.3132

0.0616

2

CYP1A2

15

rs762551

74749576

CYP1A2*1 F, +733A > C, intron 1

A

A/C

0.3201

0.4380

0.2796

3

CYP1A2

15

rs2470890

74755085

CYP1A2*1B, +6242 T > C, exon 7, N516N (syn)

C

T/C

0.4036

0.9720

0.3981

4

CYP1A2

15

rs17861162

74756412

+7569C > G, downstream 3′

C

C/G

0.0626

0.1604

0.0592

1

CYP1B1

2 (rev)

rs162562

38070372

+5810 T > G, 3′UTR

T

T/G

0.2187

0.6694

0.2701

2

CYP1B1

2 (rev)

rs1800440

38070996

CYP1B1*4, +5186 T > C, exon 3, N453S

T

T/C

0.1958

0.0068

0.1588

3

CYP1B1

2 (rev)

rs1056837

38071007

+5175G > A, exon 3, D449D (syn)

G

G/A

0.3976

0.7988

0.4692

4

CYP1B1

2 (rev)

rs1056836

38071060

CYP1B1*3, +5122C > G, exon 3, L432V

C

C/G

0.3976

0.8169

0.4716

5

CYP1B1

2 (rev)

rs1056827

38075034

CYP1B1*2, +1148C > A, exon 2, A119S

A

C/A

0.2892

0.5234

0.2962

6

CYP1B1

2 (rev)

rs10012

38075247

CYP1B1*2, +935G > C, exon 2, R48G

C

G/C

0.2903

0.5741

0.2986

7

CYP1B1

2 (rev)

rs162558

38076937

−756 T > C, promoter

T

T/C

0.1720

0.1846

0.2085

8

CYP1B1

2 (rev)

rs2855655

38077346

−1165C > T, promoter

C

C/T

0.3658

0.7345

0.4431

9

CYP1B1

2 (rev)

rs162557

38078309

−2128G > A, promoter

G

G/A

0.2376

0.2224

0.2536

10

CYP1B1

2 (rev)

rs162556

38079312

−3131A > G, promoter

A

A/G

0.5000

0.0348

0.4526

11

CYP1B1

2 (rev)

rs162555

38080367

−4186 T > C, promoter

T

T/C

0.1750

0.1664

0.2014

12

CYP1B1

2 (rev)

rs10175368

38080719

−4538C > T, promoter

C

C/T

0.2853

0.0613

0.2559