Fig. 12
From: Transcriptome analysis reveals manifold mechanisms of cyst development in ADPKD
Response to stimulus and cellular processes are abnormal in ADPKD. Both NC-ADPKD and C-ADPKD cells have higher-than-normal expression of genes in the ‘response to stimulus’ gene sets (1–8), except that C-ADPKD cells have lower-than-normal expression of genes in the ‘response to endogenous stimulus’ gene set. C-ADPKD cells have higher-than-normal expression of genes in the ‘cellular processes’ gene sets (9–11). Data are represented as mean ± s.e.m., **P < 0.01, *P < 0.05 (black asterisk is in comparison to NK, gray asterisk is in comparison to NC-ADPKD). Response to Stimulus Gene Sets: (1) RESPONSE_TO_ENDOGENOUS_STIMULUS, (2) RESPONSE_TO_EXTERNAL_STIMULUS, (3) REGULATION_OF_RESPONSE_TO_STIMULUS, (4) DEFENSE_RESPONSE, (5) CELLULAR_DEFENSE_RESPONSE, (6) RESPONSE_TO_WOUNDING, (7) COAGULATION, (8) BLOOD_COAGULATION. Cellular Processes Gene Sets: (9) KEGG_TIGHT_JUNCTION, (10) KEGG_GAP_JUNCTION, (11) LOCOMOTORY_BEHAVIOR