Fig. 13
From: Transcriptome analysis reveals manifold mechanisms of cyst development in ADPKD
Ion homeostasis and transport are abnormal in ADPKD. NC-ADPKD cells have higher-than-normal and C-ADPKD cells have much higher-than-normal expression of genes in ‘ion homeostasis’ gene sets (1–8). NC-ADPKD cells have higher-than-normal expression of genes in ‘transport’ gene sets (9–11). We represent data as mean ± s.e.m, **P < 0.01, *P < 0.05 (black asterisk is in comparison to NK, gray asterisk is in comparison to NC-ADPKD). Ion Homeostasis Gene Sets: (1) ION_HOMEOSTASIS, (2) CELLULAR_CATION_HOMEOSTASIS, (3) ION_TRANSPORT, (4) METAL_ION_TRANSPORT, (5) CATION_TRANSPORT, (6) POTASSIUM_ION_TRANSPORT, (7) CALCIUM_ION_TRANSPORT, (8) MONOVALENT_INORGANIC_CATION_TRANSPORT. Transport Gene Sets: (9) KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION, (10) KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION, (11) REGULATION_OF_BODY_FLUID_LEVELS