Fig. 9
From: Transcriptome analysis reveals manifold mechanisms of cyst development in ADPKD
Nucleotide metabolism is abnormal in ADPKD. NC-ADPKD cells have higher-than-normal expression and C-ADPKD cells have lower-than-normal expression of genes from all ‘Nucleotide Metabolism’ gene sets. We present data as mean ± s.e.m., **P < 0.01, *P < 0.05 (black asterisk is in comparison to NK, gray asterisk is in comparison to NC-ADPKD). Nucleotide Metabolism Gene Sets: (1) KEGG_PURINE_METABOLISM, (2) KEGG_PYRIMIDINE_METABOLISM, (3) RNA_SPLICING, (4) MRNA_METABOLIC_PROCESS, (5) NEGATIVE_REGULATION_OF_TRANSCRIPTION, (6) REGULATION OF NUCLEOBASE_NUCLEOSIDE_NUCLEOTIDE_AND_NUCLEIC_ACID_METABOLIC_PROCESS, (7) RNA_BIOSYNTHETIC_PROCESS, (8) NEGATIVE_REGULATION_OF NUCLEOBASE_NUCLEOSIDE_NUCLEOTIDE_AND_NUCLEIC_ACID_METABOLIC_PROCESS, (9) CHROMOSOME_ORGANIZATION_AND_BIOGENESIS, (10) DNA_METABOLIC_PROCESS