Transcriptome analysis of bronchoalveolar lavage fluid from children with severe Mycoplasma pneumoniae pneumonia reveals novel gene expression and immunodeficiency

Wang, Kuo; Gao, Man; Yang, Mingyue; Meng, Fanzheng; Li, Deli; Lu, Ruihua; Wang, Yan; Zhuang, Huadong; Li, Mengyao; Cheng, Genhong; Wang, Xiaosong

doi:10.1186/s40246-017-0101-y

Human Genomics

Table 3 Down-regulated genes of the severe MPP group comparing to the mild MPP group

From: Transcriptome analysis of bronchoalveolar lavage fluid from children with severe Mycoplasma pneumoniae pneumonia reveals novel gene expression and immunodeficiency

Gene ID	Associated gene name	log₂foldchange	padj	Description
ENSG00000163687	DNASE1L3	−4.90655	0.002613	Deoxyribonuclease I-like 3
ENSG00000166428	PLD4	−4.12788	0.005539	Phospholipase D family member 4
ENSG00000269404	SPIB	−3.62528	0.008687	Spi-B transcription factor (Spi-1/PU.1 related)
ENSG00000081059	TCF7	−2.83313	0.021184	Transcription factor 7 (T cell specific, HMG-box)
ENSG00000156738	MS4A1	−3.80125	0.029750	Membrane-spanning 4-domains, subfamily A, member 1
ENSG00000159958	TNFRSF13C	−3.59110	0.029750	Tumor necrosis factor receptor superfamily member 13C
ENSG00000233308	OSTN-AS1	−7.65241	0.029750	OSTN antisense RNA 1
ENSG00000253364	RP11-731F5.2	−5.82530	0.029750	–
ENSG00000111796	KLRB1	−3.80851	0.032804	Killer cell lectin-like receptor subfamily B, member 1
ENSG00000164485	IL22RA2	−7.13138	0.032804	Interleukin 22 receptor subunit alpha 2
ENSG00000253998	IGKV2-29	−6.19209	0.032804	Immunoglobulin kappa variable 2–29 (gene/pseudogene)
ENSG00000168542	COL3A1	−6.89272	0.036862	Collagen, type III, alpha 1
ENSG00000170801	HTRA3	−4.50354	0.036862	HtrA serine peptidase 3
Novel00339	–	−3.48127	0.041780	–
ENSG00000142173	COL6A2	−4.69524	0.042554	Collagen, type VI, alpha 2
ENSG00000100721	TCL1A	−4.49274	0.044977	T cell leukemia/lymphoma 1A
ENSG00000142156	COL6A1	−4.52065	0.044977	Collagen, type VI, alpha 1
ENSG00000111732	AICDA	−3.71025	0.055876	Activation-induced cytidine deaminase
ENSG00000164692	COL1A2	−3.75418	0.059895	Collagen, type I, alpha 2
ENSG00000105369	CD79A	−3.63713	0.069048	CD79a molecule
ENSG00000276775	IGHV4-4	−5.43537	0.069048	Immunoglobulin heavy variable 4-4
ENSG00000080573	COL5A3	−3.37399	0.090838	Collagen, type V, alpha 3
ENSG00000163518	FCRL4	−4.51056	0.090838	Fc receptor-like 4
ENSG00000196092	PAX5	−2.93710	0.093937	Paired box 5
ENSG00000177455	CD19	−3.44060	0.110361	CD19 molecule
ENSG00000136573	BLK	−3.67317	0.128424	BLK proto-oncogene, Src family tyrosine kinase
ENSG00000203963	C1orf141	−6.39692	0.130273	Chromosome 1 open reading frame 141
ENSG00000258752	RP11-356K23.1	−4.39265	0.130273	–
ENSG00000167483	FAM129C	−2.78386	0.148367	Family with sequence similarity 129 member C
ENSG00000215218	UBE2QL1	−3.91473	0.149275	Ubiquitin conjugating enzyme E2Q family-like 1
ENSG00000050165	DKK3	−3.95056	0.186854	Dickkopf WNT signaling pathway inhibitor 3
ENSG00000132185	FCRLA	−3.11003	0.186854	Fc receptor-like A
ENSG00000183853	KIRREL	−5.37583	0.186854	Kin of IRRE like (drosophila)
ENSG00000117215	PLA2G2D	−2.60098	0.191201	Phospholipase A2 group IID

log ₂ foldchange log₂ (severe MPP/mild MPP), padj adjusted p value, Novel novel gene

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ISSN: 1479-7364

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