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Fig. 3 | Human Genomics

Fig. 3

From: Whole transcriptome analysis of human erythropoietic cells during ontogenesis suggests a role of VEGFA gene as modulator of fetal hemoglobin and pharmacogenomic biomarker of treatment response to hydroxyurea in β-type hemoglobinopathy patients

Fig. 3

TagSNPs across the VEGFA gene are associated with disease phenotype (a) and HU treatment efficacy (b). a disease phenotype, rs3024997 (G>A; healthy individuals vs. NTDT patients p = 0.005; β-thalassemia major patients vs. NTDT patients p = 0.003) and rs2146323 (C>A; healthy individuals vs. β-thalassemia major patients p = 0.03; healthy individuals vs. NTDT patients p = 0.0005; β-thalassemia major patients vs. NTDT patients p = 0.009). b HU treatment efficacy, rs2146323 (C>A; HU responders vs. HU non-responders p = 0.0002). HU: hydroxyurea

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