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Fig. 4 | Human Genomics

Fig. 4

From: Recessive VARS2 mutation underlies a novel syndrome with epilepsy, mental retardation, short stature, growth hormone deficiency, and hypogonadism

Fig. 4

Computational structural analysis of mutant: Homology model of the VARS2 tRNA synthetase domain, based on the PDB id 1gax (36% sequence id, RaptorX p value 1.12e-19). a The C-terminal coiled-coild domain is shown in cyan. R1217 is highlighted with carbon atoms shown in green. tRNA is shown with orange backbone. b Inlay: Zoom of the indicated region. H1217 is shown with gray carbon atoms. The tRNA D loop is shown with carbon atoms in magenta

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Human Genomics

ISSN: 1479-7364