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Table 3 Clinical and biochemical characteristics in the normotensive controls and HTN patient subgroups according to the PAM rs13175330 genotype

From: The peptidylglycine-α-amidating monooxygenase (PAM) gene rs13175330 A>G polymorphism is associated with hypertension in a Korean population

PAM rs13175330 Normotensive controls (n = 1610) HTN group (n = 543)
HTN w/o therapy (n = 377) HTN w/ therapy (n = 166)
AA (n = 1377) G allele (n = 233) AA (n = 305) G allele (n = 72) AA (n = 129) G allele (n = 37)
Systolic BP (mmHg) 116.2 ± 0.31 117.7 ± 0.74 144.6 ± 0.68 147.9 ± 1.46* 123.2 ± 0.90 123.4 ± 1.70
Diastolic BP (mmHg) 72.6 ± 0.23 73.3 ± 0.58 91.4 ± 0.45 93.8 ± 1.11* 75.7 ± 0.63 83.3 ± 1.67***
Triglyceride (mg/dL)a 119.4 ± 2.02 121.1 ± 4.29 148.2 ± 5.10 163.9 ± 12.7 141.3 ± 6.79 148.4 ± 9.93
Total-cholesterol (mg/dL)a 198.0 ± 0.96 198.6 ± 2.53 201.7 ± 2.06 194.1 ± 4.43 193.8 ± 3.01 194.5 ± 5.97
HDL-cholesterol (mg/dL)a 54.0 ± 0.37 53.5 ± 0.84 50.3 ± 0.73 50.4 ± 1.45 50.7 ± 1.20 49.7 ± 1.98
LDL-cholesterol (mg/dL)a 121.1 ± 0.88 121.1 ± 2.20 122.7 ± 1.99 112.0 ± 3.71* 115.5 ± 2.66 115.1 ± 4.63
Glucose (mg/dL)a 95.5 ± 0.55 96.5 ± 1.47 103.7 ± 1.49 104.8 ± 3.76 105.7 ± 2.08 97.5 ± 2.56*
Insulin (μIU/dL)a 9.07 ± 0.13 9.26 ± 0.28 9.60 ± 0.33 12.1 ± 0.99** 9.56 ± 0.38 10.4 ± 0.79
HOMA-IRa 2.14 ± 0.04 2.21 ± 0.08 2.50 ± 0.11 3.29 ± 0.41** 2.45 ± 0.11 2.40 ± 0.17
LDL particle size (nm)a 23.9 ± 0.04 24.0 ± 0.06 24.0 ± 0.07 23.5 ± 0.12** 24.0 ± 0.09 23.9 ± 0.17
Oxidized LDL (U/L)a 45.9 ± 0.56 47.4 ± 1.53 49.8 ± 1.27 55.0 ± 2.70* 43.7 ± 2.09 43.7 ± 2.85
  1. Mean ± SE
  2. HTN hypertension, HTN w/o therapy HTN group treated without antihypertensive therapy, HTN w/ therapy HTN group treated with antihypertensive therapy, BP blood pressure, HDL high-density lipoprotein, LDL low-density lipoprotein, HOMA-IR homeostatic model assessment of insulin resistance, PAM peptidylglycine-α-amidating monooxygenase
  3. p < 0.1, * p < 0.05, ** p < 0.01, and *** p < 0.001 derived from an independent t test within the normotensive controls and each HTN subgroup
  4. aTested following logarithmic transformation