Table 3 Clinical and biochemical characteristics in the normotensive controls and HTN patient subgroups according to the PAM rs13175330 genotype

From: The peptidylglycine-α-amidating monooxygenase (PAM) gene rs13175330 A>G polymorphism is associated with hypertension in a Korean population

PAM rs13175330	Normotensive controls (n = 1610)				HTN group (n = 543)
	Normotensive controls (n = 1610)				HTN w/o therapy (n = 377)				HTN w/ therapy (n = 166)
	AA (n = 1377)		G allele (n = 233)		AA (n = 305)		G allele (n = 72)		AA (n = 129)		G allele (n = 37)
Systolic BP (mmHg)	116.2	± 0.31	117.7	± 0.74^†	144.6	± 0.68	147.9	± 1.46^*	123.2	± 0.90	123.4	± 1.70
Diastolic BP (mmHg)	72.6	± 0.23	73.3	± 0.58	91.4	± 0.45	93.8	± 1.11^*	75.7	± 0.63	83.3	± 1.67^***
Triglyceride (mg/dL)^a	119.4	± 2.02	121.1	± 4.29	148.2	± 5.10	163.9	± 12.7	141.3	± 6.79	148.4	± 9.93
Total-cholesterol (mg/dL)^a	198.0	± 0.96	198.6	± 2.53	201.7	± 2.06	194.1	± 4.43	193.8	± 3.01	194.5	± 5.97
HDL-cholesterol (mg/dL)^a	54.0	± 0.37	53.5	± 0.84	50.3	± 0.73	50.4	± 1.45	50.7	± 1.20	49.7	± 1.98
LDL-cholesterol (mg/dL)^a	121.1	± 0.88	121.1	± 2.20	122.7	± 1.99	112.0	± 3.71^*	115.5	± 2.66	115.1	± 4.63
Glucose (mg/dL)^a	95.5	± 0.55	96.5	± 1.47	103.7	± 1.49	104.8	± 3.76	105.7	± 2.08	97.5	± 2.56^*
Insulin (μIU/dL)^a	9.07	± 0.13	9.26	± 0.28	9.60	± 0.33	12.1	± 0.99^**	9.56	± 0.38	10.4	± 0.79
HOMA-IR^a	2.14	± 0.04	2.21	± 0.08	2.50	± 0.11	3.29	± 0.41^**	2.45	± 0.11	2.40	± 0.17
LDL particle size (nm)^a	23.9	± 0.04	24.0	± 0.06	24.0	± 0.07	23.5	± 0.12^**	24.0	± 0.09	23.9	± 0.17
Oxidized LDL (U/L)^a	45.9	± 0.56	47.4	± 1.53	49.8	± 1.27	55.0	± 2.70^*	43.7	± 2.09	43.7	± 2.85

Mean ± SE
HTN hypertension, HTN w/o therapy HTN group treated without antihypertensive therapy, HTN w/ therapy HTN group treated with antihypertensive therapy, BP blood pressure, HDL high-density lipoprotein, LDL low-density lipoprotein, HOMA-IR homeostatic model assessment of insulin resistance, PAM peptidylglycine-α-amidating monooxygenase
^† p < 0.1, ^* p < 0.05, ^** p < 0.01, and ^*** p < 0.001 derived from an independent t test within the normotensive controls and each HTN subgroup
^aTested following logarithmic transformation

Back to article page

ISSN: 1479-7364

Contact us

General enquiries: journalsubmissions@springernature.com