Genomic variants in the FTO gene are associated with sporadic amyotrophic lateral sclerosis in Greek patients

Table 2 Genotyping data of sALS patients and their healthy counterparts

Population groups		Genotype frequency (%)
		FTO rs2892469				FTO rs1861869				FTO rs17217144				FTO rs7186521				TBC1D1 rs6850200
		CC	TT	CT	p value	CC	GG	CG	p value	CC	TT	CT	p value	AA	GG	AG	p value	AA	CC	CA	p value
Second patient cohort	Greek healthy individuals	26	36	38	0.005	21	41	38	0.003	0	0	100	PA = 1.55e⁻¹² PB = 7.78e⁻¹³	0	0	100	1.0	18	45	38	0.017
Second patient cohort	Greek sALS patients	17	22	61	0.005	17	22	61	0.003	22	13	65	PA = 1.55e⁻¹² PB = 7.78e⁻¹³	0	0	100	1.0	9	35	57	0.017
Third patient cohort	Greek healthy individuals	26	36	38	0.033	21	41	38	PA = 0.072 PB = 0.071	6	2	92	0.002	0	0	100	5.13e⁻³⁹	14	43	43	0.723
	Greek sALS patients	21	23	56	0.033	17	29	54	PA = 0.072 PB = 0.071	22	2	76	0.002	18	65	18	5.13e⁻³⁹	11	42	48	0.723
	Sardinian healthy individuals	38	25	38	0.63	36	31	33	0.61	24	36	40	0.67	35	22	42	0.64	20	41	39	0.53
	Sardinian sALS patients	31	28	41	0.63	29	34	37	0.61	27	30	43	0.67	29	25	46	0.64	15	39	46	0.53
	Turkish healthy individuals	26	26	49	0.62	0	100	0	0.49	26	26	49	0.62	26	26	49	0.09	18	45	38	0.57
	Turkish sALS patients	24	21	55	0.62	0	99	1	0.49	26	20	54	0.62	21	26	53	0.09	13	44	43	0.57

ISSN: 1479-7364