Table 2 CONDOR communities that contain Sherlock-derived genes or putative COPD GWAS gene interactors
Community ID | Sherlock or interactor gene(s) | Total SNPs | Sub-threshold SNPs | Total genes | Number of differentially expressed genes | Number of differentially methylated genes | Expression meta-p value | Methylation meta-p value |
|---|---|---|---|---|---|---|---|---|
98** | HMGB1 | 143 | 0 | 4 | 3 | 1 | 2.26E-19 | 0.0028 |
113** | CDH23 | 489 | 0 | 12 | 2 | 1 | 0.0184 | 4.95E-05 |
135** | CD79A | 1959 | 0 | 162 | 29 | 13 | 9.27E-11 | 4.27E-33 |
202** | CHRNA5, HNRNPAB, IREB2, PCBP2 | 293 | 57 | 17 | 4 | 1 | 0.0032 | 0.0026 |
218** | ZNF652 | 410 | 0 | 47 | 8 | 3 | 0.0017 | 4.85E-06 |
222** | ACVR1B | 790 | 0 | 67 | 12 | 9 | 0.0003 | 8.23E-16 |
223** | RPL23A | 509 | 4 | 32 | 10 | 6 | 3.26E-06 | 8.82E-18 |
20* | WDR47 | 476 | 0 | 6 | 3 | 0 | 0.0021 | – |
78* | CHIAP2 | 631 | 0 | 18 | 3 | 1 | 0.0907 | 0.0019 |
131 | AHSA2 C2orf74 | 599 | 8 | 4 | 1 | 0 | 0.0634 | – |
161* | SMG6 | 633 | 0 | 18 | 1 | 2 | 0.3723 | 3.38E-09 |
179* | DSP | 68 | 0 | 7 | 3 | 0 | 0.0060 | – |
181* | FSTL5 | 475 | 0 | 23 | 4 | 1 | 0.0503 | 0.0069 |
187* | SNRPB | 178 | 0 | 14 | 1 | 2 | 0.5669 | 0.0001 |
210 | CTSH | 439 | 5 | 12 | 0 | 0 | 0.5741 | – |
249 | TRIM4 | 555 | 0 | 11 | 3 | 0 | 0.0957 | – |